Banner Congress EUSAAT 2013 - Linz 2013 - esnats conference


Download the abstractbook here (high resolution, 36 mb). Or with a low resolution here (4 mb).

Title of the poster Authors

 Postersession I - Sunday, September 15th, 2013 

 Progress in 3Rs' research - EU FP6 and FP7 projects 
The COSMOS Project - Developing Integrated Computational Approaches to Predict Repeated Dose Toxicity Judith Madden, Andrea Richarz, Daniel Neagu, Chihae Yang, Elena Fioravanzo, Alexandre Pery, Andrew Worth, Michael Berthold, Mark Cronin
 3Rs go 3D 
Monitoring of multilayer development of human 3D cornea constructs by trans-epithelial impedance measurement Joachim Wiest, Anja Steininger, Toni Lindl
3D Organotypic cultures of liver cells for metabolism and toxicity testing Fozia Noor
A human liver 3D cell model for substance testing Christine Schäfer, Klaus R. Schröder, Mohammad Reza Lornejad-Schäfer
 Basic and biomedical research 
Evaluation of two new recombinant Factor C based assays as alternatives for Limulus blood based endotoxin detection methods Johannes Reich, Wolfgang Mutter, Holger Grallert
Comparison of standard and fetal-calf-serum-free cell culture media by impedance measurement Joachim Wiest, Roman Kolar, Irmela Ruhdel
Topical application of cationic membrane-active peptides: enzymatic degradation by human skin ex vivo and the effect on skin penetration Günther Weindl, Nhung Do, Mario Salwiczek, Beate Koksch, Monika Schaefer-Korting
A New Organotypic 3-D Human Small Intestinal Tissue Model Reconstructed from Primary Human Cells Seyoum Ayehunie, Zachary Stevens, Timothy Landry, Alex Armento, Mitchell Klausner, Patrick Hayden
 Human on a chip 
A novel, flexible method for assessing barrier tissue integrity Roisin Owens
“Skin on a Chip” - Perfused long term culture of skin tissue Ilka Wagner, Beren Atac, Gerd Lindner, Frank Sonntag, Roland Lauster, Uwe Marx
Dynamic culture of human liver equivalents inside a micro-bioreactor for long-term substance testing Tobias Hasenberg, Eva-Maria Materne, Caroline Frädrich, Ute Süßbier, Reyk Horland, Silke Hoffmann, Sven Brincker, Alexandra Lorenz, Mathias Busek, Frank Sonntag, Roland Lauster, Uwe Marx
 Disease Models 
Next Generation Sequencing (NGS) approaches to detect fixed point mutations in human airway epithelia Klaus Sommer, Elke Bradt, Samuel Constant, Damien Breheny, Klaus R. Schröder
Investigation into the inflammatory response of the H292 lung epithelial model to cigarette smoke particulate generated using different smoking regimes and reduced toxicant prototypes Sarah Corke, Linsey Haswell, Katherine Hewitt Hewitt, Geoff Foss-Smith, David Azzopardi, Gary Phillips
In Vitro Non-Melanoma Skin Cancer Model for Toxicity Testing and Pre-Clinical Drug Evaluation Christian Zoschke, Nesrin Alnasif, Emanuel Fleige, Rainer Haag, Hans F Merk, Günther Weindl, Sarah Küchler, Monika Schaefer-Korting
Novel 3-D reconstructed human tissues model of psoriatic skin Seyoum Ayehunie, C. Hedin, Timothy Landry, M. Spratt, M Clark, T. Kupper, Mitchell Klausner
Human epidermis reconstructed from UVB-irradiated keratinocytes mimics premature ageing in human skin Lilian Julia Löwenau, Suvara Wattanapitayakul, Johanna M. Brandner, Günther Weindl, Monika Schaefer-Korting
Alterations of canalicular and basolateral transporters by cyclosporin A in human HepaRG® cells Ahmad SHARANEK, Pamela BACHOUR-EL AZZI, Christiane Guguen-Guillouzo, Andre GUILLOUZO
 GCCP - Good cell culture practice 
Human Platelet Lysates Successfully Replace Fetal Bovine Serum  in Adipose-derived Adult Stem Cell Culture Caroline Rauch, Elisabeth Feifel, Gerhard Gstraunthaler
Human Platelet Lysates Promote the Differentiation Potential  of Adipose-derived Adult Stem Cell Cultures Caroline Rauch, Elisabeth Feifel, Angelika Flörl, Kristian Pfaller, Gerhard Gstraunthaler
Importance of reproducibility demonstration of the bio-engineered tissue models used for in vitro toxicity testing purposes Silvia Letasiova, Helena Kandarova, Michael Bachelor, Paul Kearney, Mitchell Klausner
 Drugs, vaccines and medical devices 
Construction of an Impedance monitoring system for cell seeding and drug screening in a 3D cell culture model Christine Schäfer, Wolfgang Hilber, Klaus R. Schröder, Berhard Jakoby, Mohammad Reza Lornejad-Schäfer
Confocal µ-Raman spectroscopy of living cells Susanne Kimeswenger, Krisztina-Andrea Vincze-Minya, Klaus R. Schröder, Sabine Hild, Mohammad Reza Lornejad-Schäfer
In Vitro Phototoxicity Screening Assay for Systemically Administered Pharmaceuticals Using a Reconstructed Skin Model EpiDerm Yulia Kaluzhny, M. W. Kinuthia, Patrick Hayden, Laurence d’Argembeau-Thornton, Helena Kandarova, Mitchell Klausner
 Free Communications 
Non-testing strategies - a tiered approach R. Arno Wess
In vitro toxicity testing: influence of different cell lines and endpoints Pavel Kosina, Adéla Galandáková, Sylva Snášelová, Jitka Ulrichová
Ologen® Collagen Matrix: a new dermal scaffold for skin tissue engineering Suzan Commandeur, Sarah Sparks, Lisanne van Zijl, Marion Rietveld, Horng Ji Lai, Chien C. Lin, Abdoel El Ghalbzouri
Alternative methods in education:  what do students think? Francesca Caloni, Alexis Theodoridis, Vangelis Kehagias, Cristina Cortinovis, Fabiola Pizzo, Magdalini Sachana
Improving cadaveric models for surgery teaching and training Maria Claudia Inglez de Souza, Antonio Augusto Ribeiro, Julia Maria Matera
Animal Testing and Transparency – a Contradiction in Terms? Presenting a Project to Promote both, Transparency of Animal Testing and the Social Dialogue between Proponents and Opponents Vera Marashi, Norbert Alzmann, Herwig Grimm
HuIFN-αN3 inducing capacity of the Newcastle disease virus (NDV) ZG1999HDS FILIPIC BRATKO, Adriana Pereyra, Mazija Hrvoje, EUGEN ŠOOŠ, JANA POTOKAR, SRECKO KOREN
The Lush Prize – Supporting Animal Free Testing K. Brown and R. Harrison
InterNICHE outreach and replacement of animal experiments in education in Uzbekistan and Kyrgyzstan Nick Jukes and Dmitry Leporsky
Humane education and ethical science: Campaigning for replacement in Iran Ramak Roshanaie and Nick Jukes

 Postersession ESNATS, Monday, September 16th, 2013 

 ESNATS - embryonic stem cells 
Development of a microfluidic biochip for chronic monitoring of 3D neural tissues derived from human Embryonic Stem Cells Luc Stoppini, Antonin Sandoz, Igor Charvet
Epigenetically-conserved biomarkers of an undifferentiated human embryonic stem cell phenotype Steve Pells, Eirini Koutsouraki, Sofia Morfopoulou, Sara Valencia-Cadavid, Andy Malinowski, Rachel Riddoch, Simon Tomlinson, Ravi Kalathur, Matthias Futschik, Paul De Sousa
Elucidation of perturbed pathways by using stem cell derived neural  progenitors Dimitra Zagoura, Francesca Pistollato, Jochem Louisse, Silvia Colleoni, Giovanna Lazzari, Agapios Sachinidis, Susanne Bremer
Testing neurodevelopmental toxicity on differentiating human embryonic stem cells Anne-Catherine FEUTZ, Christian DE GEYTER
Development of a neural teratogenicity test: comparative microarray analysis of two different hESCs lines following exposure to valproic acid Silvia Colleoni, Cesare Galli, John Antony Gaspar, Kesavan Meganathan, Smita Jagtap, Jürgen Hescheler, Susanne Bremer, Agapios Sachinidis, Giovanna Lazzari
Qualification of neural differentiation protocols and points to consider when transferring standardized protocols between laboratories. Orla O'Shea, Lyn Healy, Glyn Stacey
The role of dioxygenases in human embryonic stem cells Eirini Koutsouraki, Steve Pells, Paul De Sousa
Defining compound subcytotoxic effects on epigenetic determinants of human embryonic stem cell renewal and lineage commitment Eirini Koutsouraki, Paul De Sousa
Human Embryonic Stem Cells Differentiation Reveals Toxicity Signatures for HDAC inhibitors and Mercuric Toxicants Kesavan Meganathan, Smita Jagtap, Sureshkumar Perumal Srinivasan, Vaibhav Shindev, Vilas Wagh, Jürgen Hescheler, Agapios Sachinidis

 Postersession II, Tuesday, September 17th, 2013 

 Directive 2010/63/EU and implementation into national legislation 
The harm:benefit assessment under the new Directive 2010/63- will any projects be rejected? Katy Taylor
„Taking Ethical Considerations Into Account? Methods to Carry Out the Harm-Benefit Analysis According to the EU Directive 2010/63/EU“. Summary of a Symposium at the Messerli Research Institute Vera Marashi, Norbert Alzmann, Herwig Grimm
 Regulatory toxicity testing & 2013 marketing ban for cosmetics 
Review of REACH from an animal protection perspective Katy Taylor
How many animals have been really used for REACH purposes: appraisal after the second deadline Costanza Rovida
REACH – Who is responsible for ensuring that animal testing is conducted only as a last resort? Gilly Stoddart
The way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance? Tatyana Doktorova, Gamze Ates, CHRISTOPHE CHESNE, Tamara Vanhaecke, Vera Rogiers
Acute toxicity of alcohols determined by alternative methods Marian Rucki, Kristina Kejlova, Dagmar Jirova
Analysis of the Validated Epiderm Skin Corrosion Test (EpiDerm SCT) and a Prediction Model for Sub-Categorization According to the UN GHS and EU CLP. Helena Kandarova, Silvia Letasiova, Tatiana Milasova, Patrick Hayden, Mitchell Klausner
 Specific toxicological endpoints 
Are structural analogs to bisphenol A a safe alternative? Anne Marie Vinggaard
A ‘low toxicity profile’ can waive the 90-day repeated dose test for REACH Katy Taylor
Dialogue with EFSA to avoid useless animal testing in the area of genotoxicity Costanza Rovida, Mario Aquino
Development and characterization of a bioengineered conjunctiva model on the basis of immortalized cells Michaela Zorn-Kruppa, Melinda Bartok, Detlef Gabel, Maria Engelke, Kerstin Reisinger, Karolina Daton, Karsten Mewes, Johanna M. Brandner
In silico models for dermal absorption from complex formulations Katharina Guth, Jim Riviere, Jim Brooks, Monika Schaefer-Korting, Martina Dammann, Eric Fabian, Bennard van Ravenzwaay, Robert LANDSIEDEL
Alternative Method in practice: postvalidation experience of the skin sensitization in vitro test strategy Susanne N Kolle, Annette Mehling, Naveed Honarvar, Wera Teubner, Bennard van Ravenzwaay, Robert LANDSIEDEL
Neurotoxicity in vitro: assessment of the predictivity of neuronal networks coped to microelectrode arrays for identification of neurotoxicants Tzutzuy Ramirez Hernandez, Timo Weisschu, Hans-Albrecht Huener, Bennard van Ravenzwaay, Robert LANDSIEDEL
Screening of a large group of medical substances and environmental pollutants in a neural crest stem-cell based functional migration assay Giorgia Pallocca, Bastian Zimmer, Nadine Dreser, Sunniva Foerster, Nina Balmer, Stephanie Julien, Karl-Heinz Krause, Sieto Bosgra, Marcel Leist
Using the Slug Mucosal Irritation assay to predict discomfort caused by ophthalmic formulations Joke Lenoir, Ilse Claerhout, Philippe Kestelyn, Jean-Paul Remon, Els Adriaens
Study on development for the alternative methods for photo-toxicity and photo-genotoxicity tests using mouse keratinocytes and human 3D skin model So Young Kim, Yong Kyoung Lee, Mi Hyang Nam, Chea Hyung Lim, Jun Young Yang, Il Young Ahn, Ki Hwan Choi
Results of a (pre)validation study of the Hen’s Egg Test for Micronucleus-Induction (HET-MN) Katrin Maul, Dagmar Fieblinger, Andreas Heppenheimer, Juergen Kreutz, Andreas Luch, Ralph Pirow, Albrecht Poth, Kerstin Reisinger, Pamela Strauch, Thorsten Wolf
Characterization of lymphoblastoid cell lines as a novel in vitro test system to predict immunotoxicity of xenobiotics Tijana Markovic, Martina Gobec, David Gurwitz, Irena Mlinaric-Rascan
Evaluation of the sub-classification of dermal corrosives  in vitro using the epiCS® (CellSystems) reconstructed human skin model Dirk Weisensee, Oliver Engelking, Tanja Klein, Daniel Fuchs, Horst Fuchs
The human placenta in toxicology Udo Markert, Andre Schmidt, Claudia Göhner, Jana Pastuschek, Maja Weber
Neurospheres as a predictive 3D in vitro model for DNT testing and pathway investigation in a species-specific context. Ellen Fritsche, Kathrin Gassmann, Susanne Giersiefer, Janette Schuwald, Jenny Baumann
The DNT-EST: a predictive embryonic stem cell test for developmental neurotoxicity testing in vitro. Andrea Seiler, Katrin Hayess, Christian Riebeling, Ralph Pirow, Matthias Steinfath, Dana Sittner, Birgitta Slawik, Konrad Gulich, Andreas Luch
Optimization of the EpiOcular Eye Irritation Test for Hazard Identification and Labelling of Chemicals in Response to the Requirements of the EU Cosmetic Directive and REACH Legislation Yulia Kaluzhny, Helena Kandarova, Laurence d’Argembeau-Thornton, J. De Luca, Patrick Hayden, Amy Hunter, Thoa Truong, Mitchell Klausner
Improving genotoxicity testing to avoid or minimize the number of animals: an EURL ECVAM proposal Federica Madia, Raffaella Corvi, Andrew Worth and Maurice Whelan
Studies on the mode of action of Multi-walled Carbon Nanotubes onto human bronchial epithelial cells Dorothee Walter, Monika Niehof, Anja Hackbarth, Tanja Hansen
Molecular Recognition Force Microscopy/Spectroscopy Peter Hinterdorfer, Lilia Chtcheglova
Genotoxicity of nanosized TiO2 particles in human reconstructed full thickness skin models Dagmar Fieblinger
Genotoxicity of nanosized Titanium dioxide particles in 16HBE14o- cells Mario Gotz
In vitro toxicology of air samples: Breathe or not to breathe? Anita Érseková, Jana Klánová, John Giesy, Jiři Novak
 Ethical & legal issues 
Use of Animals and Alternatives in Military Medical Training by NATO Nations Justin Goodman
 Toxicology in the 21st century 
Verification of Systems Biology Research in the Age of Collaborative- Competition Marja Talikka
Moving forward: a new paradigm for drug discovery. Meg Lewis, J Malcolm Wilkinson
Human 3D corneal models for a detailed quantification of the initial depth of injury as an indicator for cellular damage in the human eye Melinda Bartok, Detlef Gabel, Maria Engelke, Michaela Zorn-Kruppa, Johanna M. Brandner, Kerstin Reisinger, Karolina Daton, Karsten Mewes
Coupling of the BALB/c-3T3 cell transformation assay to a metabolic activation system and to the soft agar colony formation assay: determination of two endpoints in a single in vitro test system Maria Daniela Brauneis, Pablo Steinberg
What is relevant? Martin Paparella, Mardas Daneshian, Romana Hornek-Gausterer, Maximilian Kinzl, Ilse Mauritz, Simone Mühlegger
Using 21st Century toxicology to model disease risk Karina McQuillan

From Biotech to FDA: Validation of in Vitro Methods of Prediction of Human Toxicity

Robert A Coleman