21st European Congress on Alternatives to Animal Testing, September 23-26 2018, University of Linz, Austria

Program per day

(preliminary, v. 21.09.2018; please note: some chairs have to be confirmed)

Download the electronic version of the abstractbook here.

Sunday, 23 September 2018
Opening & Keynote Lecture 13:00-13:45
HALL 1    
15 min   Welcome addresses
30 min   Application of Human Multi-Organ-Chips to Enhance Safety and Efficacy Assessment in Drug Discovery
Reyk Horland
Vice-President, TissUse GmbH,
DE-Berlin
Scientific sessions 13:50-15:20
HALL 1
   
1.1 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) I - Perfusion & Lung
Chairs: Andreas Stucki, CH-Bern
(the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize)
20 min   Bioprinting Perfusion-Enabled Liver Equivalents for Advanced Organ-on-a-Chip Applications
Tobias Grix, DE-Berlin 
15 min   Characterization of a lung/liver organ-on-a-chip model
David Bovard, CH-Neuchâtel 
15 min   3D bioprinting of lung and liver models for viral infection and transduction with viral gene vectors
Johanna Berg, DE-Berlin 
15 min   Lung-on-a-Chip: The interplay of primary human epithelial and endothelial cells improves the alveolar barrier function
Andreas Stucki, CH-Bern
12 min   Microfluidic engineering of vascular networks by growth factor gradient control
Barbara Bachmann, AT-Vienna 
13 min   General discussion
HALL 2
   
5 Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy
Chairs:  Gabriele Scholz, CH-Lausanne
25 min   More animal testing for less human safety? How animals continue to suffer for our (novel) food and why oral toxicity tests should be replaced
Tilo Weber
, DE-Neubiberg
25 min   In vitro fluid-dynamic intestinal device as fast and reliable approach for food nutrients permeation tests
Silvia Scaglione, IT-Genova 
25 min   Methodological Improvements and Automation for Better Biodetection of Endocrine Activities In-Vitro
Karma Fussell
, CH-Lausanne
15 min   General discussion
15:20-16:00   Coffee break and posters
Scientific sessions 16:00-17:30  
HALL 1
   
12 International Progress in 3Rs Research
Chairs: Erin Hill, US-Gaithersburg
20 min   Predictive Toxicology, Strategies for Implementing New Approaches Outcomes of the 7th Annual Meeting of the American Society for Cellular and Computational Toxicology
Erin Hill, US-Gaithersburg
20 min   Consensus Ways of Alternative to Animal Testing in China
Shu Jun Cheng, CN-Shanghai
20 min   3Rs Centre in Sri Lanka to promote 'Replacement' concept
Stefanie Schindler
, CH-Bern
20 min   INDIA: Launching of a National Society for Alternatives to Animal Experiments
Mohammad A. Akbarsha
, IN-Tiruchirappalli
10 min   General discussion
HALL 2
   
4 Advanced Safety Testing of Cosmetics and Consumer Products
Chairs: Gabriele Scholz, CH-Lausanne, and Jochen Kühnl, DE-Hamburg
20 min   Newly validated 3D skin genotoxicity assays improve safety assessments of cosmetic ingredients
Rodger Curren, US-Gaithersburg
20 min   Inter-and intra-laboratory reproducibility of the in vitro photo-toxicity test using 3D reconstructed human epidermis model EpiDerm
Helena Kandarova, SK-Bratislava
20 min   Inconsistent effects of chemical filters in UV/ROS stress cell models
Stefanie Hofer, AT-Innsbruck
20 min   European Institutions Still Need to Close the Door on Animal-Tested Cosmetics
Julia Baines, GB-London
10 min   General discussion
Round table I 17.35-18.35
HALL 1    
    International Progress in 3Rs Research
    Moderator
Erin Hill, ASCCT, US-Gaithersburg
Panelists
Shujun Cheng, CCARE, CN-Guangzhou & Shanghai
Roger Curren, IIVS, US-Gaithersburg
Stefanie Schindler, AnimalfreeResearch, CH-Bern
18:45   Welcome reception (at the congress venue)
Monday, 24 September 2018
Keynote lecture 09:00-09:30   
HALL 1
   
30 min   The Netherlands Initiative "Phasing out the Use of Experimental Animals within a 10 Year Period?"
Herman B.W.M. Koëter
Managing Director, Orange House Partnership, BE-Brussels & Chairman of NCad, the Netherlands National Committee for the protection of animals used for scientific purposes (NCad), NL-The Hague
Scientific sessions 09:35-11:05  
HALL 1    
1.2 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) II - Woundhealing - Bone & Skin
Chairs: Johanna Brandner, DE-Hamburg
(the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize)

20 min   Development of an in vitro human-based multicomponent 3D joint model as basis for the simulation of an arthritic joint model
Alexandra Damerau, DE-Berlin
awarded with the YSTA 2018
20 min   Mimicking the initial phase of fracture healing in vitro
Moritz Pfeiffenberger, DE-Berlin
20 min   Re-epithelialization in Focus: Non-invasive Monitoring of Epidermal Wound Closure in Vitro Using Organotypic Skin Models
Lisa Kiesewetter, DE-Würzburg
15 min   Cartilage-on-a-Chip: the future of osteoarthritis modeling and drug screening?
Julie Rosser, AT-Vienna
15 min   Utilization of in vitro and ex vivo wound healing models to address different aspects of cutaneous wound healing and drug testing
Johanna Brandner, DE-Hamburg
HALL 2
   
18 Update on Implementing EU Dir 63/2010
Chairs: Susanna Louhimies, BE-Brussels, and Henriette Bout, NL-Den Haag
20 min   Directive 2010/63/EU – progress, challenges and future directions
Susanna Louhimies, BE-Brussels
15 min   Transition to animal-free research - on possibilities for phasing out animal experiments and stimulating animal-free innovation
Henriette Bout, NL-Den Haag
15 min   Understanding and implementation of the 3Rs of animal welfare bodies at German research facilities and universities
Carolin Spicher, DE-Munich
15 min   Meta-analysis of NTSs ameliorates identification of research areas for 3R development
Bettina Bert, DE-Berlin
15 min   Severity classification: curse or blessing?
Anne Zintzsch, DE-Giessen
10 min   Decision making on the possible handling of laboratory animals after a trial
Mechthild Ladwig-Wiegard, DE-Berlin
HALL 3
   
3.1 3Rs in Education and Academia - Creating Awareness by Education and Training to Enhance Animal Welfare in Science
Chairs: Annemarie Lang, DE-Berlin, and Julia Steitz, DE-Aachen
15 min   Alternative approaches in education provide excellent refinement measures
Christa Thöne-Reineke, DE-Berlin
15 min   ReThink3R: Design Thinking Workshops for Young Scientists – Awareness and Innovation for the 3Rs
Laura Behm, DE-Potsdam
awarded with the YSTA 2018
15 min   Practical Guidance in LAS-Continuing Professional Development
Pieter Verbost, NL-Utrecht
15 min   The Laboratory Animal Science and Welfare course at University of Debrecen
Ádám Deák, HU-Debrecen
15 min   Animal welfare right from the start: The 3Rs concept as a guiding principle in veterinary training
Stephanie Krämer, DE-Giessen
15 min   ‘Everyone is responsible’ - animal welfare in the education
Györgyi Szabó, HU-Budapest
11:05-11:35   Coffee break and posters 
 paid advertising

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Scientific sessions 11:35-13:05
HALL 1
   
1.3 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) III - Specific Organs
Chairs: Peter Loskill, DE-Stuttgart, and Bhumika Singh, GB-Rotherham
(the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize)

20 min   Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip technology for complex multi-layer tissue models
Kevin Achberger, DE-Tübingen
awarded with the YSTA 2018
20 min   Merging high-content and higher-throughput screening: Microphysiological Organ-on-a-Chip systems integrating human retinal, cardiac and adipose tissue
Peter Loskill, DE-Stuttgart
20 min   Development of a multi-organ in vitro model of the interactions between liver and cardiac cells under uni-directional dynamic flow
Bhumika Singh, GB-Rotherham
15 min   Characterization of chemical metabolism in combined skin and liver models over extended and repeated exposure in a multi organ chip device
Jochen Kühnl, DE-Hamburg
15 min   General Discussion
HALL 2
   
14.1 Refinement & Reduction I- Culture of Care and Translational Research
Chairs: Stefanie Schindler, CH-Bern and Julia Steitz, DE-Aachen
15 min   Culture of Care – from words to action
Susanna Louhimies, BE-Brussels
15 min   Measuring fecal testosterone metabolites in house mice: replacement of invasive techniques
Kerstin E- Thonhauser, AT-Vienna
15 min   Different cultures of care for lab animals – a comparative study of practices at universities and private research institutions in Denmark
Thomas Lund, DK-Frede
15 min   Measuring Culture of Care – a practical example
Thomas Bertelsen, DK-Maaloev
15 min   Rehoming of former laboratory animals
Henriette Bout, NL-Den Haag
15 min   Translational failures call for critical appraisal of animal studies
Kathrin Herrmann, US-Baltimore
HALL 3
   
19 Vaccines & The 3Rs: New Methods and Developments (e.g. Batch Release Testing)
Chairs: Coenraad Hendriksen, NL-Bilthoven
20 min   Human Rabies vaccine glycoprotein G ELISA as an alternative to the challenge test: selection of a candidate method and future strategies
Jean Michel Chapsal, BE-Brussels
20 min   Development of an in vitro potency assay for Zika Purified Inactivated Vaccine (ZPIV)
Stephanie Richard, FR-Marcy l'Etoile
20 min   Vaccine batch to vaccine batch comparison by consistency testing (VAC2VAC)
Hilde Depraetere, DE-Heidelberg
15 min   Bacterially expressed nanobodies can replace secondary antibody production in animals
Dirk Görlich, DE-Göttingen
15 min   General discussion
13:05-14:00   Business lunch (to be served at the congress venue) and posters
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Scientific sessions 14:00-15:30
HALL 1
   
8.1 Ecotoxicology I - Focus on diverse ecotoxicological endpoints
Chairs: Marlies Halder, IT.Ispra, and Kristin Schirmer, CH-Dübendorf
20 min   Ecological Threshold for Toxicological Concern (eco-TTC) - Applications for Environmental Risk Assessment in Various Contexts
Marlies Halder, IT-Ispra
15 min   Prediction of acute fish toxicity of fragrance chemicals: the RTgill-W1 cell assay as a simple, accurate and reliable alternative to the fish in vivo test
Lu Hostettler, CH-Dübendorf
20 min   FISH on CHIPS: Development of a novel in vitro system of the fish intestine
Carolin Drieschner, CH-Dübendorf
awarded with the YSTA 2018
awarded with the Young Scientist Best Oral Award 2018 for the second best oral presentation
20 min   Predicting chemical impact on fish growth by combining computational modelling with in vitro fish cell line responses
Kristin Schirmer, CH-Dübendorf
15 min    Using mechanisms of toxic action to classify and predict ester ecotoxicity
Pascal Bicherel, FR-L’Isle D’Abeau
HALL 2
   
2.1 3R Centers in Europe - National and Local Centers - part I
Chairs: Chantra Eskes, CH-Bern, and Susanna Louhimies, BE-Brussels
15 min   The National Centre for the 3Rs
Jan Ragan, GB-London
15 min   Swiss 3R Competence Centre: Promoting research & education on 3Rs
Chantra Eskes, CH-Bern
15 min   Towards implementation of the 3Rs in basic research and teaching in Italy: Centro 3R
Arti Ahluwalia, IT-Pisa
12 min   The Slovak National Platform for 3Rs - SNP 3Rs
Helena Kandarova, SK-Bratislava
20 min   National Committees under Directive 2010/63/EU and Three Rs centres – complementing one another for a win-win
Susanna Louhimies, BE-Brussels
13 min   General discussion
HALL 3
   
15 Replacement – Advanced Technologies for Implementation of 3Rs
Chairs: Barbara Birk, DE-Ludwigshafen
20 min   Patient-specific, additively manufactured vascular models enabling an animal-free neurointerventional training setup
Juliane Kuhl, DE-Hamburg
20 min   A biotechnological metabolic activation system – Potential for replacing rat liver S9 fractions
Andreas Schiwy, DE-Aachen
20 min   Development of an additive manufactured mouse phantom for quality assurance of a small animal irradiation device
Marie F. E. Wegner, DE-Hamburg
15 min   Metabolome analysis in vitro in NRK-52e cells might allow the prediction of nephrotoxicity and its mode of action
Barbara Birk, DE-Ludwigshafen
15 min   Establishment of a model for Equine Grass Sickness: extracorporeal blood perfusion of equine ileum
 Maria Unterköfler, AT-Vienna
15:30-16:00   Coffee break and posters  
Scientific sessions 16:00-17:30
HALL 1    
9 Efficacy and Safety Testing of Drugs, Medical Devices & Biopharmaceutics
Chairs: Klaus Schröder, AT-Linz
15 min   Using a concerted analysis of corresponding cellular assays to create a complete in vitro bone culture and implant testing system
Daniel Seitz, DE-Bayreuth
15 min   3D in vitro cardiac model established from fish larvae for application in pharmacology
Bianka Grunow, DE-Dummerstorf
15 min   Efficacy testing of antivirals using human upper and small airway epithelia
Samual Constant, CH-Plan-les-Ouates
15 min   Successful Development and Validation of the EpiDerm In Vitro Skin Irritation Protocol for the Assessment of Medical Devices extracts
Helena Kandarova, SK-Bratislava
15 min   The Nonclinical Innovation and Patient Safety Initiative (NIPSI): Supporting Human-Based Nonclinical Approaches Through Advances in Law, Policy, Education and Training in the United States
Elizabeth Baker
, US-Washington
15 min   Rapid Development of anti-idiotypic binders using a novel affinity scaffold
Toni Hoffmann
, GB-Wetherby
HALL 2    
2.2 3R Centers in Europe - National and Local Centers - part II
Chairs: Monika Schäfer-Korting, DE-Berlin, and Julika Fitzi-Rathgen, CH-Basel
15 min   Collaboration and complementarity within Three Rs centres
Adelaide Dura, IT-Ispra
15 min   Berlin – Bundling 3R Expertise in the German Capital
Monika Schäfer-Korting, DE-Berlin
12 min   Animal protection and 3R in Switzerland
Julika Fitzi-Rathgen, CH-Basel
12 min   3Rs at the University of Zurich
Paulin Jirkof, CH-Zurich
12 min   'ICar3R' - a New Interdisciplinary Centre for 3Rs in Animal Research of the Justus Liebig University Giessen
Stephanie Krämer, DE-Giessen
15 min   MUI animalFree Research Cluster
Doris Wilflingseder, AT-Innsbruck
9 min   General discussion
HALL 3    
7.1 Disease Models Using HUMAN Cells, Tissues and Organs - Tumors & Other Disease Models
Chairs: Gudrun Dandekar, DE-Würzburg, and Beate Rinner, AT-Graz
20 min   A combined in silico-3D lung tumor model to understand network effects of driver mutations for targeted therapy predictions
Gudrun Dandekar, DE-Würzburg 
15 min   Establishment of a New Cholangiocarcinoma Cell Line MUG-CCArly1
Florian Kleinegger, AT-Graz 
20 min   Investigation on ex-vivo functional interactions between tumor cells and lymphoblastoid cells in chordoma
Beate Rinner, AT-Graz 
20 min   Disease models using human cells: 3D in-vitro models for metabolic diseases show translation in diabetes and liver fibrosis
Patrick Guye, CH-Schlieren 
15 min   Extracellular Vesicles – Mighty Players in Chordoma Communication?
Ines Anders
, AT-Graz
Round table II 17:35-18:35
HALL 1    
    3R Centers in Europe - National and Local Centers
    Moderator
Susanna Louhimies, EU, BE-Brussels
Panelists
Arti Ahluwalia, Centro 3R, IT-Genoa
Chantra Eskes, 3RCC, CH-Bern
Ian Ragan, NC3R, GB-London
Monika Schaefer-Korting, BB3R, DE-Berlin
Stephanie Kraemer, ICar3R, DE-Giessen
Judith Lechner, MUI Animal Free Research Cluster, AT-Innsbruck
Poster session I 18:35-20:00
POSTER HALL  
    Poster session with coffee
Survey of the posters with presence of the authors
EUSAAT AGA 20:15-22:15
HALL 2    
    Annual General Assembly of EUSAAT (members only)
Tuesday, 25 September 2018
Keynote lecture 09:00-09:30  
HALL1    
30 min   Generating Human Organ Models by 3D Bioprinting
Jens Kurreck
Director, Inst. Biotechnology, Applied Biochemistry, TU Berlin,
DE-Berlin
Scientific sessions 09:35-11:05
HALL 1    
8.2 Ecotoxicology II - Focus on metabolism and bioaccumulation
Chairs: Dominik Rünzler, AT-Vienna, and Christopher Fassbender, GB-London
15 min   Ability of three rainbow trout (Onchorhynchus mykiss) cell lines to eliminate benzo(a)pyrene and extrapolation to derive a fish bioconcentration factor
Kristin Schirmer, CH-Dübendorf
15 min   Xenobiotic metabolism in the fish hepatic cell lines Hepa-E1 and RTH-149, and the gill cell lines RTgill-W1 and G1B: biomarkers of CYP450 activity and oxidative stress
Marco Franco, US-Waco
awarded with the YSTA 2018
15 min   Comparability of the in vitro RTgutGC (Rainbow trout) intestinal cell line to native gastrointestinal tissue
Laura Langan, GB-Plymouth
15 min   Tissue specific response of organoids to the model compound pyrene in rainbow trout 3D co-cultures
Laura Langan, GB-Plymouth
15 min   Development of OECD Test Guidelines and Guidance Document on determination of fish in vitro hepatic clearance
Marlies Halder
, IT-Ispra
15 min   Benchmarking study to support regulatory acceptance of the application of in vitro-in vivo extrapolation to predict the bioaccumulation potential of fragrance chemicals
Lu Hostettler, CH-Dübendorf
HALL 2
   
6 Biological Barriers
Chairs: Maxime Culot, FR-Lens, and Winfried Neuhaus, AT-Vienna
15 min   Development of an advanced primary in vitro model of the human small intestine
Matthias Schweinlin, DE-Würzburg
15 min   iPSC-derived renal proximal tubular cells: development and evaluation for their application in nephrotoxicity studies
Anja Wilmes, NL-Amsterdam
15 min   An improved in vitro model of the oral mucosa epithelium for biomarker research and transport studies: Optimization by media supplements and airlift cultivation
Grace Lin, AT-Vienna
15 min   Genetically modified 3D human in vitro lung models
Samual Constant, CH-Plan-les-Ouates
15 min   Microfluidic strategies for nanomaterial risk assessment at in vitro organ barrier models
Mario Rothbauer, AT-Vienna
15 min   Human induced pluripotent stem cell based in vitro models of the blood-brain barrier: A promise for the future of drug testing, toxicity and disease modelling
Winfried Neuhaus, AT-Vienna
HALL 3
   
3.2 3Rs in Education and Academia - Teaching and Applying Alternatives in Education and Training
Chairs: Anna Maria Bassi, IT-Genova, and Györgyi Szabó, HU-Budapest
20 min   Training and Teaching in Substitutive Approaches to Animal Testing: the commitment of Italian Academia
Anna Maria Bassi, IT-Genova 
15 min   Implementation of 3R in veterinary education through virtual patients
Lena Vogt, DE-Berlin
awarded with the YSTA 2018
15 min   Towards animal -free methods in education and training: Lessons from healthcare
Luisa Bastos, BE-Brussels 
15 min   Lung Simulation – An Alternative Approach to Animal Testing for Applications in Aerosol and Respiratory Research
Mathias Forjan, AT-Vienna 
15 min   Teaching 3R principles in ecotoxicology by performing a problem-based learning project
Rita Leitner, AT-Vienna
12 min   The Alternatives in Education and Academia: what is happening across EU
Candida Nastrucci, IT-Rome 
11:05-11:35   Coffee break and posters
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Scientific sessions 11:35-13:05 
HALL 1    
11 In Silico Models: Toxicology & Efficacy of Drugs, Chemicals & Cosmetics
Chairs: Günter Klambauer, AT-Linz
15 min   In Silico Tools to Assist the Development of Physiologically-Based Kinetic Models: Identification, Characterisation and Use
Judith Madden, GB-Liverpool
15 min   Computational Methods for the Prediction of Chemical Toxicity
Priyanka Banerjee, DE-Berlin
15 min   Modelling oxygen consumption in brain organoids
Arti Ahluwalia, IT-Pisa
15 min   In-silico tool to design cyp3a5 silensomestm using T-5 substrate and lapatinib as mechanism-based inhibitor
Ashwani Sharma, FR-Saint-Grégoire
15 min   An in Silico Lung Tumor Model for Drug Efficacy Screening and Optimal Clinical Therapy as Alternative to Animal Testing
Meik Kunz, DE-Würzburg
awarded with the YSTA 2018
15 min   General discussion
HALL 2
   
13 In vitro Techniques for CNS Toxicity and Disease Studies
Chairs: Winfried Neuhaus, AT-Vienna, and Maxime Culot, FR-Lens
20 min   Stem cell-based human blood-brain barrier co-culture models for pre-clinical development
Marco Metzger
, DE-Würzburg
15 min   Advanced human in vitro blood-brain barrier disease models for cerebral ischemia
Anna Gerhartl, AT-Vienna
20 min   Modelling ischemic stroke injury at the blood-brain barrier in vitro using induced pluripotent stem cells
Abraham Alahmad, US-Amarillo
15 min   Microfluidic-embedded 3D networks of iPSC-derived neurons and glia, for highly-predictive mechanistic neurotoxicity screening
Karlijn Wilschut, NL-Leiden
20 min   Microelectrode array (MEA) recordings of neuronal activity as in vitro tool to assess acute and developmental neurotoxicity
Remco Westerink, NL-Utrecht
HALL 3
   
10 Free Communications
Chairs: Dagmar Jirová, CZ-Prague, and Györgyi Szabó, HU-Budapest
20 min   Cellular senescence: a response pathway within AOPs?
Johannes Grillari, AT-Vienna
15 min   Gene edited non-human primates (NHPs) – further ethical challenges. And the responsibility of scientific journals
Ismene Fertschai, AT-Graz
20 min   Comparative analysis of the difference of toxicity test between Chinese and European Pharmacopoeia
Mao Ling Wei, CN-Chengdu
20 min   A review of REACH from the animal perspective
Katy Taylor, GB-London
15 min   General discussion
13:05-14:00   Business lunch (to be served at the congress venue) and posters
Scientific sessions 14:00-15:30
HALL 1    
1.4 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) IV - Intestinal Systems
Chairs: Martin Raasch, DE-Jena, and Stefanie Schindler, CH-Bern
(the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize)
20 min   Emulating the Gut-Liver Axis - Organ-on-chip as Translational Tool in Sepsis Research
Martin Raasch, DE-Jena
20 min   Reconstructed 3D Model of Human Small Intestine for Prediction Of Gastrointestinal Toxicity and Drug Absorption
Jan Markus, SK-Bratislava
20 min   Human intestinal organoids as model for studying drug transport
Tamara Zietek, DE-Cologne
15 min   High-throughput, perfused intestinal tubules for real-time assessment of drug-induced barrier disruption
Karlijn Wilschut, NL-Leiden
15 min   General Discussion
HALL 2
   
14.2 Refinement & Reduction II - Refinement and Avoidance of Severe Suffering
Chairs: Annemarie Lang, DE-Berlin
20 min   Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
Katharina Hohlbaum, DE-Berlin
15 min   Evaluating tramadol and buprenorphine applied via the drinking water as pain medication in a mouse osteotomy model
Mattea Durst, CH-Zurich
15 min   Animal Centric Strategies for Severity Assessment and Refinement
Lars Lewejohann, DE-Berlin
15 min   Focus on severe suffering: how reducing suffering can be a gateway to replacement
Elliot Lilley, GB-Horsham
15 min   Refinement by systematic severity scorings in animal experiments
Kristina Ullmann, DE-Berlin
10 min   Minimising suffering in energy deprived rats
Majken Dalgaard, DK-Måløv
HALL 3
   
17 Stem Cell Models (hiPS, ES, mES, miPS)
Chairs: Regina Grillari, AT-Vienna, and Filomain Nguemo, DE-Köln
20 min   Modelling sporadic Alzheimer's disease using patient derived iPSCs
Andras Dinnyes, HU-Godollo
20 min   Alternative research methods for challenging disease: human iPS derived Parkinson’s-on-chip
Julie Rosser, AT-Vienna
20 min   A new approach for animal free carcinogenicity testing using MN as biomarker (PMNvit)
Bastian Niklas Hölzel, DE-Aarbergen
15 min   Carp Stem Cells Growth on Chorioallantoic Membrane of Fertilized Hen's Egg
Mahmoud Galal, EG-Cairo
15 min   Modeling sex differences in vitro
Judith Lechner, AT-Innsbruck
15:30-16:00   Coffee break and posters  
Scientific sessions 16:00-17:30   
HALL 1
   
1.5 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) V - Future Applications
Chairs: Helena Kandarova, SK-Bratislava, and Jochen Kühnl, DE-Hamburg
(the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize)

20 min   Tomorrow today: organ-on-a-chip advances towards clinically relevant pharmaceutical and medical in vitro models
Peter Ertl, AT-Vienna
15 min   Microphysiological flux balance platform unravels the dynamics of drug induced steatosis
Muneef Ayyash, IL-Jerusalem
15 min   Importance of computational modelling in the design of Organ on a Chip Devices
Bhumika Singh, GB-Rotherham
12 min   Impact of Spheroidal Age on Drug Toxicity and Diffusivity
Christoph Eilenberger, AT-Vienna
15 min   3D Models and Multi-Organ-Chips: Scaffold-free 3D tissue models – from static to microphysiological applications
Oliver Frei, CH-Schlieren
13 min   General Discussion
HALL 2
   
7.2 Disease Models Using HUMAN Cells, Tissues and Organs - Lung & Infection
Chairs: Stefan Hippenstiel, DE-Berlin, and Samuel Constant, CH-Plan-les-Ouates
20 min   A human lung ex vivo infection model
Stefan Hippenstiel, DE-Berlin
15 min   Human cell- and tissue-based models of the lungs in state of health and disease
Nicole Schneider-Daum, DE-Saarbrücken
12 min   Modeling respiratory bacterial infections using in vitro human airway epithelia
Samual Constant, CH-Plan-les-Ouates
15 min   3D Epithelial Culture Model to Study Chlamydia Infection
Munir Al-Zeer, DE-Berlin
15 min   hAELVi cells as an in vitro inflammation model
Julia Katharina Metz, DE-Saarbrücken
13 min   General discussion
HALL 3
   
16.1 Specific Endpoints of Toxicity I
Chairs: Rodger Curren, US-Gaithersburg, and Robert Landsiedel, DE-Ludwigshafen
20 min   Evaluation of retinoic acid receptor alpha (RARα) interaction of chemicals by combining two techniques to a new screening approach
Barbara Birk, DE-Ludwigshafen
20 min   Non-animal methods for skin sensitisation testing - is there really a need for integrated testing strategies?
David Roberts, GB-Liverpool
20 min   Pre-validation of an Acute Inhalation Toxicity Test Using the EpiAirway In Vitro Human Airway Model
Silvia Letasiova, SK-Bratislava
15 min   The added value of the 90-day repeated dose test for substances of low (sub) acute toxicity for REACH purposes
Katy Taylor, GB-London
15 min   General discussion
Round table III 17:35-18:35
HALL 1    
    Applying human 3D models and Multi-Organ-Chips (MOCs) in Industry
    Moderator
Winfried Neuhaus, AIT, AT-Vienna
Panelists

Samuel Constant, Epithelix & Oncotheis, CH-Plan-les-Ouates
Helena Kandarova, MatTek, SK-Bratislava (to be confirmed)
Jochen Kuehnl, Beiersdorf, DE-Hamburg
Robert Landsiedel, BASF, DE-Ludwigshafen
Peter Ertl, Vienna University of Technology, AT-Vienna
Poster session II 18:35-20:00
POSTER HALL
 
    Poster session with coffee
Survey of the posters with presence of the authors
20.15   Departure to the Social Evening
20.30   Social Evening
Wednesday, 26 September 2018
Keynote lecture 09:00-09:30
HALL 1
   
30 min   Having a Successful Career in in vitro Toxicology: Pillars of Success
Helena Kandarova
Executive Director, MatTek IVLSL (In Vitro Life Science Laboratories),
SK-Bratislava
Scientific sessions 09:35-11:05
 HALL 1
   
20.1  'Young Scientists' session I
Chairs: Christian Zoschke, DE-Berlin, and Kristina Wagner, DE-Neubiberg
12 min   The hen’s egg test on the chick area vasculosa (HET-CAV) as a test system to evaluate the antimicrobial activity of drugs and formulations
Paul Warncke, DE-Jena
awarded with the YSTA 2018
12 min   Comparison of Breathing Patterns for Aerosol Inhalation Using an Electro-mechanical Lung Simulator
Richard Paštěka, AT-Vienna
awarded with the YSTA 2018
12 min   Off-target effects of novel purine-analog phosphonates for anti-cancer therapy
Christian Zoschke, DE-Berlin
12 min   A dynamic model of the alveolar interface for the study of aerosol deposition
Roberta Nossa
, IT-Pisa
awarded with the YSTA 2018
12 min   Human buffy-coat derived platelet lysate: comparison of single-patient and pooled units for the cultivation of different human cell lines
Michelle Hesler, DE-Sulzbach
awarded with the YSTA 2018
awarded with the Young Scientist Best Oral Award 2018 for the best oral presentation
12 min   Organ-on-a-chip meets traction force microscopy: In situ characterization of forces in 3D micro-tissues
Stefanie Fuchs, DE-Stuttgart
awarded with the YSTA 2018
18 min   General discussion
HALL 2
   
14.3 Refinement & Reduction III - Increase Transparency and Use Existing Infrastructures to Reduce the Lab Animal Usage
Chairs: Christa Thöne-Reineke, DE-Berlin, and Christiane Hohensee, DE-Aachen
20 min   Sharing is Caring – Update on innovative approaches to share organs and tissues to reduce the lab animal usage
Annemarie Lang, DE-Berlin
20 min   The elephant in the room: PREPARE before you ARRIVE
Adrian Smith
, NO-Oslo
20 min   It´s time to rethink: learn from negative results in animal based research! Critical Incident Reporting System in Laboratory Animal Science CIRS-LAS.DE
Sabine Bischoff
, DE-Jena
15 min   Promoting transparency in preclinical research: preregistration of preclinical studies on www.preclinicaltrials.eu
Mira van der Naald
, NL-Utrecht
15 min   The Horse as Model for Osteoarthritis Research – Research Tools vs. Stakeholders
Annemarie Lang, DE-Berlin
HALL 3
   
16.2 Specific Endpoints of Toxicity II
Chairs: Dagmar Jirová, CZ-Prague
20 min   Impedance spectroscopy as a method to discriminate between all GHS categories for eye irritation in vitro
Christian Lotz
, DE-Würzburg
20 min   Integrating Knowledge Of Carcinogenicity Adverse Outcome Pathways (AOPs) With Experimental Data
Steven Kane, GB-Leeds
20 min   In vitro methods for identifying substances with endocrine disruption potential
Marketa Dvorakova, CZ-Prague
15 min   Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate proliferation of granulosa tumor via IGF1R - 3D cell culture model
Justyna Gogola, PL-Krakow
awarded with the YSTA 2018
15 min   General discussion
 11:05-11:35   Coffee break and posters  
Scientific sessions 11:35-13:05
HALL 1    
20.2  'Young Scientists' session II
Chairs: Dominik Rünzler, AT-Vienna, and Winfried Neuhaus, AT-Vienna
12 min   Co-Cultivation of myofibroblasts and adipocytes provides new insights into hypertrophic scar regeneration
Katharina Hörst, DE-Berlin
awarded with the YSTA 2018
awarded with the Young Scientist Best Oral Award 2018 for the third best oral presentation
12 min   Development of advancing human 3D trabecular meshwork models to assess onset of Glaucoma
Sara Tirendi, IT-Genova
awarded with the YSTA 2018
12 min   3Rs in Education - Systematical Evaluation of Simulators for Rats and Mice
Melanie Humpenöder, DE-Berlin
awarded with the YSTA 2018
12 min   Bioinformatics analysis of IPS cell data to elucidate mechanisms of actions of nephrotoxins
Pranika Singh, CH-Basel
12 min   SimulRator – Manufacturing a 3D-printed simulator of the rat for laboratory animal training courses
Giuliano Mario Corte, DE-Berlin
awarded with the YSTA 2018
12 min   Chronic lymphocytic leukemia cells as an in vitro model in preclinical drug evaluation
Tijana Markovic, SI-Ljubljana
18 min   General discussion
HALL 2    
7.3 Disease Models Using HUMAN Cells, Tissues and Organs - Skin Tumor Models
Chairs: Monika Schäfer-Korting, DE-Berlin, and Stefanie Schindler, CH-Bern
20 min   Normal human skin and atopic dermatitis models – penetration and efficacy of topical glucocorticoids
Monika Schäfer-Korting, DE-Berlin
20 min   Human cell-based tumor microenvironment models for improved preclinical drug development
Christian Zoschke, DE-Berlin
20 min   3D melanoma skin models: unravelling the effects of the basal membrane and sub-populations of fibroblasts in tumour progression and invasion
Abdoel El Ghalbzouri, NL-Leiden
15 min   Unusual, innovative, and close to in-vivo: MUG-Mel1 and MUG-Mel2 melanoma cell lines for drug development
Beate Rinner, AT-Graz
15 min   General discussion
Closing Remarks13:10-13:30
HALL 1    
    Closing Remarks
     

 Wednesday, 26 September 2018

13:45-18:00

 

Day one
EUSAAT 2018 Practical Training Course on Alternative Methods:
"EUSAAT 2018 - Kirkstall Quasi Vivo® Training Workshop"

open to all participants of the EUSAAT 2018 Congress, registration required, for details click HERE

 Thursday, 27 September 2018

08:30-11:00
(at least)

 

Day two
EUSAAT 2018 Practical Training Course on Alternative Methods:
"EUSAAT - Kirkstall Quasi Vivo® Training Workshop"

open to all participants of the EUSAAT 2018 Congress, registration required, for details click HERE

 

Merken

Merken