Program per day
(preliminary, v. 21.09.2018; please note: some chairs have to be confirmed)
Download the electronic version of the abstractbook here.
Sunday, 23 September 2018 | ||
Opening & Keynote Lecture 13:00-13:45 | ||
HALL 1 | ||
15 min | Welcome addresses |
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30 min | Application of Human Multi-Organ-Chips to Enhance Safety and Efficacy Assessment in Drug Discovery Reyk Horland Vice-President, TissUse GmbH, DE-Berlin |
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Scientific sessions 13:50-15:20 | ||
HALL 1 |
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1.1 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) I - Perfusion & Lung Chairs: Andreas Stucki, CH-Bern (the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize) |
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20 min | Bioprinting Perfusion-Enabled Liver Equivalents for Advanced Organ-on-a-Chip Applications Tobias Grix, DE-Berlin |
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15 min | Characterization of a lung/liver organ-on-a-chip model David Bovard, CH-Neuchâtel |
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15 min | 3D bioprinting of lung and liver models for viral infection and transduction with viral gene vectors Johanna Berg, DE-Berlin |
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15 min | Lung-on-a-Chip: The interplay of primary human epithelial and endothelial cells improves the alveolar barrier function Andreas Stucki, CH-Bern |
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12 min | Microfluidic engineering of vascular networks by growth factor gradient control Barbara Bachmann, AT-Vienna |
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13 min | General discussion | |
HALL 2 |
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5 Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Chairs: Gabriele Scholz, CH-Lausanne |
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25 min | More animal testing for less human safety? How animals continue to suffer for our (novel) food and why oral toxicity tests should be replaced Tilo Weber, DE-Neubiberg |
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25 min | In vitro fluid-dynamic intestinal device as fast and reliable approach for food nutrients permeation tests Silvia Scaglione, IT-Genova |
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25 min | Methodological Improvements and Automation for Better Biodetection of Endocrine Activities In-Vitro Karma Fussell, CH-Lausanne |
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15 min | General discussion | |
15:20-16:00 | Coffee break and posters | |
Scientific sessions 16:00-17:30 | ||
HALL 1 |
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12 International Progress in 3Rs Research Chairs: Erin Hill, US-Gaithersburg |
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20 min | Predictive Toxicology, Strategies for Implementing New Approaches Outcomes of the 7th Annual Meeting of the American Society for Cellular and Computational Toxicology Erin Hill, US-Gaithersburg |
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20 min | Consensus Ways of Alternative to Animal Testing in China Shu Jun Cheng, CN-Shanghai |
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20 min | 3Rs Centre in Sri Lanka to promote 'Replacement' concept Stefanie Schindler, CH-Bern |
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20 min | INDIA: Launching of a National Society for Alternatives to Animal Experiments Mohammad A. Akbarsha, IN-Tiruchirappalli |
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10 min | General discussion | |
HALL 2 |
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4 Advanced Safety Testing of Cosmetics and Consumer Products Chairs: Gabriele Scholz, CH-Lausanne, and Jochen Kühnl, DE-Hamburg |
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20 min | Newly validated 3D skin genotoxicity assays improve safety assessments of cosmetic ingredients Rodger Curren, US-Gaithersburg |
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20 min | Inter-and intra-laboratory reproducibility of the in vitro photo-toxicity test using 3D reconstructed human epidermis model EpiDerm Helena Kandarova, SK-Bratislava |
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20 min | Inconsistent effects of chemical filters in UV/ROS stress cell models Stefanie Hofer, AT-Innsbruck |
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20 min | European Institutions Still Need to Close the Door on Animal-Tested Cosmetics Julia Baines, GB-London |
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10 min | General discussion | |
Round table I 17.35-18.35 |
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HALL 1 | ||
International Progress in 3Rs Research | ||
Moderator Erin Hill, ASCCT, US-Gaithersburg Panelists Shujun Cheng, CCARE, CN-Guangzhou & Shanghai Roger Curren, IIVS, US-Gaithersburg Stefanie Schindler, AnimalfreeResearch, CH-Bern |
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18:45 | Welcome reception (at the congress venue) | |
Monday, 24 September 2018 | ||
Keynote lecture 09:00-09:30 | ||
HALL 1 |
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30 min | The Netherlands Initiative "Phasing out the Use of Experimental Animals within a 10 Year Period?" Herman B.W.M. Koëter Managing Director, Orange House Partnership, BE-Brussels & Chairman of NCad, the Netherlands National Committee for the protection of animals used for scientific purposes (NCad), NL-The Hague |
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Scientific sessions 09:35-11:05 |
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HALL 1 | ||
1.2 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) II - Woundhealing - Bone & Skin Chairs: Johanna Brandner, DE-Hamburg (the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize) |
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20 min | Development of an in vitro human-based multicomponent 3D joint model as basis for the simulation of an arthritic joint model Alexandra Damerau, DE-Berlin awarded with the YSTA 2018 |
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20 min | Mimicking the initial phase of fracture healing in vitro Moritz Pfeiffenberger, DE-Berlin |
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20 min | Re-epithelialization in Focus: Non-invasive Monitoring of Epidermal Wound Closure in Vitro Using Organotypic Skin Models Lisa Kiesewetter, DE-Würzburg |
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15 min | Cartilage-on-a-Chip: the future of osteoarthritis modeling and drug screening? Julie Rosser, AT-Vienna |
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15 min | Utilization of in vitro and ex vivo wound healing models to address different aspects of cutaneous wound healing and drug testing Johanna Brandner, DE-Hamburg |
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HALL 2 |
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18 Update on Implementing EU Dir 63/2010 Chairs: Susanna Louhimies, BE-Brussels, and Henriette Bout, NL-Den Haag |
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20 min | Directive 2010/63/EU – progress, challenges and future directions Susanna Louhimies, BE-Brussels |
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15 min | Transition to animal-free research - on possibilities for phasing out animal experiments and stimulating animal-free innovation Henriette Bout, NL-Den Haag |
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15 min | Understanding and implementation of the 3Rs of animal welfare bodies at German research facilities and universities Carolin Spicher, DE-Munich |
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15 min | Meta-analysis of NTSs ameliorates identification of research areas for 3R development Bettina Bert, DE-Berlin |
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15 min | Severity classification: curse or blessing? Anne Zintzsch, DE-Giessen |
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10 min | Decision making on the possible handling of laboratory animals after a trial Mechthild Ladwig-Wiegard, DE-Berlin |
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HALL 3 |
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3.1 3Rs in Education and Academia - Creating Awareness by Education and Training to Enhance Animal Welfare in Science Chairs: Annemarie Lang, DE-Berlin, and Julia Steitz, DE-Aachen |
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15 min | Alternative approaches in education provide excellent refinement measures Christa Thöne-Reineke, DE-Berlin |
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15 min | ReThink3R: Design Thinking Workshops for Young Scientists – Awareness and Innovation for the 3Rs Laura Behm, DE-Potsdam awarded with the YSTA 2018 |
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15 min | Practical Guidance in LAS-Continuing Professional Development Pieter Verbost, NL-Utrecht |
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15 min | The Laboratory Animal Science and Welfare course at University of Debrecen Ádám Deák, HU-Debrecen |
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15 min | Animal welfare right from the start: The 3Rs concept as a guiding principle in veterinary training Stephanie Krämer, DE-Giessen |
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15 min | ‘Everyone is responsible’ - animal welfare in the education Györgyi Szabó, HU-Budapest |
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11:05-11:35 | Coffee break and posters | |
paid advertising |
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Scientific sessions 11:35-13:05 | ||
HALL 1 |
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1.3 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) III - Specific Organs Chairs: Peter Loskill, DE-Stuttgart, and Bhumika Singh, GB-Rotherham (the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize) |
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20 min | Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip technology for complex multi-layer tissue models Kevin Achberger, DE-Tübingen awarded with the YSTA 2018 |
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20 min | Merging high-content and higher-throughput screening: Microphysiological Organ-on-a-Chip systems integrating human retinal, cardiac and adipose tissue Peter Loskill, DE-Stuttgart |
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20 min | Development of a multi-organ in vitro model of the interactions between liver and cardiac cells under uni-directional dynamic flow Bhumika Singh, GB-Rotherham |
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15 min | Characterization of chemical metabolism in combined skin and liver models over extended and repeated exposure in a multi organ chip device Jochen Kühnl, DE-Hamburg |
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15 min | General Discussion | |
HALL 2 |
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14.1 Refinement & Reduction I- Culture of Care and Translational Research Chairs: Stefanie Schindler, CH-Bern and Julia Steitz, DE-Aachen |
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15 min | Culture of Care – from words to action Susanna Louhimies, BE-Brussels |
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15 min | Measuring fecal testosterone metabolites in house mice: replacement of invasive techniques Kerstin E- Thonhauser, AT-Vienna |
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15 min | Different cultures of care for lab animals – a comparative study of practices at universities and private research institutions in Denmark Thomas Lund, DK-Frede |
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15 min | Measuring Culture of Care – a practical example Thomas Bertelsen, DK-Maaloev |
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15 min | Rehoming of former laboratory animals Henriette Bout, NL-Den Haag |
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15 min | Translational failures call for critical appraisal of animal studies Kathrin Herrmann, US-Baltimore |
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HALL 3 |
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19 Vaccines & The 3Rs: New Methods and Developments (e.g. Batch Release Testing) Chairs: Coenraad Hendriksen, NL-Bilthoven |
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20 min | Human Rabies vaccine glycoprotein G ELISA as an alternative to the challenge test: selection of a candidate method and future strategies Jean Michel Chapsal, BE-Brussels |
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20 min | Development of an in vitro potency assay for Zika Purified Inactivated Vaccine (ZPIV) Stephanie Richard, FR-Marcy l'Etoile |
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20 min | Vaccine batch to vaccine batch comparison by consistency testing (VAC2VAC) Hilde Depraetere, DE-Heidelberg |
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15 min | Bacterially expressed nanobodies can replace secondary antibody production in animals Dirk Görlich, DE-Göttingen |
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15 min | General discussion | |
13:05-14:00 | Business lunch (to be served at the congress venue) and posters |
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paid advertising |
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Scientific sessions 14:00-15:30 |
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HALL 1 |
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8.1 Ecotoxicology I - Focus on diverse ecotoxicological endpoints Chairs: Marlies Halder, IT.Ispra, and Kristin Schirmer, CH-Dübendorf |
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20 min | Ecological Threshold for Toxicological Concern (eco-TTC) - Applications for Environmental Risk Assessment in Various Contexts Marlies Halder, IT-Ispra |
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15 min | Prediction of acute fish toxicity of fragrance chemicals: the RTgill-W1 cell assay as a simple, accurate and reliable alternative to the fish in vivo test Lu Hostettler, CH-Dübendorf |
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20 min | FISH on CHIPS: Development of a novel in vitro system of the fish intestine Carolin Drieschner, CH-Dübendorf awarded with the YSTA 2018 awarded with the Young Scientist Best Oral Award 2018 for the second best oral presentation |
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20 min | Predicting chemical impact on fish growth by combining computational modelling with in vitro fish cell line responses Kristin Schirmer, CH-Dübendorf |
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15 min | Using mechanisms of toxic action to classify and predict ester ecotoxicity Pascal Bicherel, FR-L’Isle D’Abeau |
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HALL 2 |
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2.1 3R Centers in Europe - National and Local Centers - part I Chairs: Chantra Eskes, CH-Bern, and Susanna Louhimies, BE-Brussels |
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15 min | The National Centre for the 3Rs Jan Ragan, GB-London |
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15 min | Swiss 3R Competence Centre: Promoting research & education on 3Rs Chantra Eskes, CH-Bern |
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15 min | Towards implementation of the 3Rs in basic research and teaching in Italy: Centro 3R Arti Ahluwalia, IT-Pisa |
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12 min | The Slovak National Platform for 3Rs - SNP 3Rs Helena Kandarova, SK-Bratislava |
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20 min | National Committees under Directive 2010/63/EU and Three Rs centres – complementing one another for a win-win Susanna Louhimies, BE-Brussels |
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13 min | General discussion | |
HALL 3 |
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15 Replacement – Advanced Technologies for Implementation of 3Rs Chairs: Barbara Birk, DE-Ludwigshafen |
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20 min | Patient-specific, additively manufactured vascular models enabling an animal-free neurointerventional training setup Juliane Kuhl, DE-Hamburg |
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20 min | A biotechnological metabolic activation system – Potential for replacing rat liver S9 fractions Andreas Schiwy, DE-Aachen |
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20 min | Development of an additive manufactured mouse phantom for quality assurance of a small animal irradiation device Marie F. E. Wegner, DE-Hamburg |
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15 min | Metabolome analysis in vitro in NRK-52e cells might allow the prediction of nephrotoxicity and its mode of action Barbara Birk, DE-Ludwigshafen |
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15 min | Establishment of a model for Equine Grass Sickness: extracorporeal blood perfusion of equine ileum Maria Unterköfler, AT-Vienna |
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15:30-16:00 | Coffee break and posters | |
Scientific sessions 16:00-17:30 | ||
HALL 1 | ||
9 Efficacy and Safety Testing of Drugs, Medical Devices & Biopharmaceutics Chairs: Klaus Schröder, AT-Linz |
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15 min | Using a concerted analysis of corresponding cellular assays to create a complete in vitro bone culture and implant testing system Daniel Seitz, DE-Bayreuth |
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15 min | 3D in vitro cardiac model established from fish larvae for application in pharmacology Bianka Grunow, DE-Dummerstorf |
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15 min | Efficacy testing of antivirals using human upper and small airway epithelia Samual Constant, CH-Plan-les-Ouates |
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15 min | Successful Development and Validation of the EpiDerm In Vitro Skin Irritation Protocol for the Assessment of Medical Devices extracts Helena Kandarova, SK-Bratislava |
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15 min | The Nonclinical Innovation and Patient Safety Initiative (NIPSI): Supporting Human-Based Nonclinical Approaches Through Advances in Law, Policy, Education and Training in the United States Elizabeth Baker, US-Washington |
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15 min | Rapid Development of anti-idiotypic binders using a novel affinity scaffold Toni Hoffmann, GB-Wetherby |
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HALL 2 | ||
2.2 3R Centers in Europe - National and Local Centers - part II Chairs: Monika Schäfer-Korting, DE-Berlin, and Julika Fitzi-Rathgen, CH-Basel |
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15 min | Collaboration and complementarity within Three Rs centres Adelaide Dura, IT-Ispra |
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15 min | Berlin – Bundling 3R Expertise in the German Capital Monika Schäfer-Korting, DE-Berlin |
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12 min | Animal protection and 3R in Switzerland Julika Fitzi-Rathgen, CH-Basel |
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12 min | 3Rs at the University of Zurich Paulin Jirkof, CH-Zurich |
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12 min | 'ICar3R' - a New Interdisciplinary Centre for 3Rs in Animal Research of the Justus Liebig University Giessen Stephanie Krämer, DE-Giessen |
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15 min | MUI animalFree Research Cluster Doris Wilflingseder, AT-Innsbruck |
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9 min | General discussion | |
HALL 3 | ||
7.1 Disease Models Using HUMAN Cells, Tissues and Organs - Tumors & Other Disease Models Chairs: Gudrun Dandekar, DE-Würzburg, and Beate Rinner, AT-Graz |
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20 min | A combined in silico-3D lung tumor model to understand network effects of driver mutations for targeted therapy predictions Gudrun Dandekar, DE-Würzburg |
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15 min | Establishment of a New Cholangiocarcinoma Cell Line MUG-CCArly1 Florian Kleinegger, AT-Graz |
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20 min | Investigation on ex-vivo functional interactions between tumor cells and lymphoblastoid cells in chordoma Beate Rinner, AT-Graz |
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20 min | Disease models using human cells: 3D in-vitro models for metabolic diseases show translation in diabetes and liver fibrosis Patrick Guye, CH-Schlieren |
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15 min | Extracellular Vesicles – Mighty Players in Chordoma Communication? Ines Anders, AT-Graz |
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Round table II 17:35-18:35 | ||
HALL 1 | ||
3R Centers in Europe - National and Local Centers | ||
Moderator Susanna Louhimies, EU, BE-Brussels Panelists Arti Ahluwalia, Centro 3R, IT-Genoa Chantra Eskes, 3RCC, CH-Bern Ian Ragan, NC3R, GB-London Monika Schaefer-Korting, BB3R, DE-Berlin Stephanie Kraemer, ICar3R, DE-Giessen Judith Lechner, MUI Animal Free Research Cluster, AT-Innsbruck |
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Poster session I 18:35-20:00 |
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POSTER HALL | ||
Poster session with coffee Survey of the posters with presence of the authors |
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EUSAAT AGA 20:15-22:15 | ||
HALL 2 | ||
Annual General Assembly of EUSAAT (members only) | ||
Tuesday, 25 September 2018 |
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Keynote lecture 09:00-09:30 | ||
HALL1 | ||
30 min | Generating Human Organ Models by 3D Bioprinting Jens Kurreck Director, Inst. Biotechnology, Applied Biochemistry, TU Berlin, DE-Berlin |
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Scientific sessions 09:35-11:05 |
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HALL 1 | ||
8.2 Ecotoxicology II - Focus on metabolism and bioaccumulation Chairs: Dominik Rünzler, AT-Vienna, and Christopher Fassbender, GB-London |
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15 min | Ability of three rainbow trout (Onchorhynchus mykiss) cell lines to eliminate benzo(a)pyrene and extrapolation to derive a fish bioconcentration factor Kristin Schirmer, CH-Dübendorf |
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15 min | Xenobiotic metabolism in the fish hepatic cell lines Hepa-E1 and RTH-149, and the gill cell lines RTgill-W1 and G1B: biomarkers of CYP450 activity and oxidative stress Marco Franco, US-Waco awarded with the YSTA 2018 |
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15 min | Comparability of the in vitro RTgutGC (Rainbow trout) intestinal cell line to native gastrointestinal tissue Laura Langan, GB-Plymouth |
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15 min | Tissue specific response of organoids to the model compound pyrene in rainbow trout 3D co-cultures Laura Langan, GB-Plymouth |
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15 min | Development of OECD Test Guidelines and Guidance Document on determination of fish in vitro hepatic clearance Marlies Halder, IT-Ispra |
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15 min | Benchmarking study to support regulatory acceptance of the application of in vitro-in vivo extrapolation to predict the bioaccumulation potential of fragrance chemicals Lu Hostettler, CH-Dübendorf |
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HALL 2 |
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6 Biological Barriers Chairs: Maxime Culot, FR-Lens, and Winfried Neuhaus, AT-Vienna |
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15 min | Development of an advanced primary in vitro model of the human small intestine Matthias Schweinlin, DE-Würzburg |
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15 min | iPSC-derived renal proximal tubular cells: development and evaluation for their application in nephrotoxicity studies Anja Wilmes, NL-Amsterdam |
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15 min | An improved in vitro model of the oral mucosa epithelium for biomarker research and transport studies: Optimization by media supplements and airlift cultivation Grace Lin, AT-Vienna |
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15 min | Genetically modified 3D human in vitro lung models Samual Constant, CH-Plan-les-Ouates |
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15 min | Microfluidic strategies for nanomaterial risk assessment at in vitro organ barrier models Mario Rothbauer, AT-Vienna |
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15 min | Human induced pluripotent stem cell based in vitro models of the blood-brain barrier: A promise for the future of drug testing, toxicity and disease modelling Winfried Neuhaus, AT-Vienna |
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HALL 3 |
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3.2 3Rs in Education and Academia - Teaching and Applying Alternatives in Education and Training Chairs: Anna Maria Bassi, IT-Genova, and Györgyi Szabó, HU-Budapest |
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20 min | Training and Teaching in Substitutive Approaches to Animal Testing: the commitment of Italian Academia Anna Maria Bassi, IT-Genova |
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15 min | Implementation of 3R in veterinary education through virtual patients Lena Vogt, DE-Berlin awarded with the YSTA 2018 |
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15 min | Towards animal -free methods in education and training: Lessons from healthcare Luisa Bastos, BE-Brussels |
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15 min | Lung Simulation – An Alternative Approach to Animal Testing for Applications in Aerosol and Respiratory Research Mathias Forjan, AT-Vienna |
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15 min | Teaching 3R principles in ecotoxicology by performing a problem-based learning project Rita Leitner, AT-Vienna |
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12 min | The Alternatives in Education and Academia: what is happening across EU Candida Nastrucci, IT-Rome |
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11:05-11:35 | Coffee break and posters | |
paid advertising |
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Scientific sessions 11:35-13:05 |
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HALL 1 | ||
11 In Silico Models: Toxicology & Efficacy of Drugs, Chemicals & Cosmetics Chairs: Günter Klambauer, AT-Linz |
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15 min | In Silico Tools to Assist the Development of Physiologically-Based Kinetic Models: Identification, Characterisation and Use Judith Madden, GB-Liverpool |
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15 min | Computational Methods for the Prediction of Chemical Toxicity Priyanka Banerjee, DE-Berlin |
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15 min | Modelling oxygen consumption in brain organoids Arti Ahluwalia, IT-Pisa |
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15 min | In-silico tool to design cyp3a5 silensomestm using T-5 substrate and lapatinib as mechanism-based inhibitor Ashwani Sharma, FR-Saint-Grégoire |
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15 min | An in Silico Lung Tumor Model for Drug Efficacy Screening and Optimal Clinical Therapy as Alternative to Animal Testing Meik Kunz, DE-Würzburg awarded with the YSTA 2018 |
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15 min | General discussion | |
HALL 2 |
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13 In vitro Techniques for CNS Toxicity and Disease Studies Chairs: Winfried Neuhaus, AT-Vienna, and Maxime Culot, FR-Lens |
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20 min | Stem cell-based human blood-brain barrier co-culture models for pre-clinical development Marco Metzger, DE-Würzburg |
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15 min | Advanced human in vitro blood-brain barrier disease models for cerebral ischemia Anna Gerhartl, AT-Vienna |
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20 min | Modelling ischemic stroke injury at the blood-brain barrier in vitro using induced pluripotent stem cells Abraham Alahmad, US-Amarillo |
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15 min | Microfluidic-embedded 3D networks of iPSC-derived neurons and glia, for highly-predictive mechanistic neurotoxicity screening Karlijn Wilschut, NL-Leiden |
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20 min | Microelectrode array (MEA) recordings of neuronal activity as in vitro tool to assess acute and developmental neurotoxicity Remco Westerink, NL-Utrecht |
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HALL 3 |
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10 Free Communications Chairs: Dagmar Jirová, CZ-Prague, and Györgyi Szabó, HU-Budapest |
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20 min | Cellular senescence: a response pathway within AOPs? Johannes Grillari, AT-Vienna |
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15 min | Gene edited non-human primates (NHPs) – further ethical challenges. And the responsibility of scientific journals Ismene Fertschai, AT-Graz |
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20 min | Comparative analysis of the difference of toxicity test between Chinese and European Pharmacopoeia Mao Ling Wei, CN-Chengdu |
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20 min | A review of REACH from the animal perspective Katy Taylor, GB-London |
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15 min | General discussion | |
13:05-14:00 | Business lunch (to be served at the congress venue) and posters |
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Scientific sessions 14:00-15:30 | ||
HALL 1 | ||
1.4 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) IV - Intestinal Systems Chairs: Martin Raasch, DE-Jena, and Stefanie Schindler, CH-Bern (the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize) |
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20 min | Emulating the Gut-Liver Axis - Organ-on-chip as Translational Tool in Sepsis Research Martin Raasch, DE-Jena |
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20 min | Reconstructed 3D Model of Human Small Intestine for Prediction Of Gastrointestinal Toxicity and Drug Absorption Jan Markus, SK-Bratislava |
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20 min | Human intestinal organoids as model for studying drug transport Tamara Zietek, DE-Cologne |
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15 min | High-throughput, perfused intestinal tubules for real-time assessment of drug-induced barrier disruption Karlijn Wilschut, NL-Leiden |
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15 min | General Discussion | |
HALL 2 |
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14.2 Refinement & Reduction II - Refinement and Avoidance of Severe Suffering Chairs: Annemarie Lang, DE-Berlin |
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20 min | Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia Katharina Hohlbaum, DE-Berlin |
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15 min | Evaluating tramadol and buprenorphine applied via the drinking water as pain medication in a mouse osteotomy model Mattea Durst, CH-Zurich |
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15 min | Animal Centric Strategies for Severity Assessment and Refinement Lars Lewejohann, DE-Berlin |
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15 min | Focus on severe suffering: how reducing suffering can be a gateway to replacement Elliot Lilley, GB-Horsham |
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15 min | Refinement by systematic severity scorings in animal experiments Kristina Ullmann, DE-Berlin |
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10 min | Minimising suffering in energy deprived rats Majken Dalgaard, DK-Måløv |
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HALL 3 |
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17 Stem Cell Models (hiPS, ES, mES, miPS) Chairs: Regina Grillari, AT-Vienna, and Filomain Nguemo, DE-Köln |
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20 min | Modelling sporadic Alzheimer's disease using patient derived iPSCs Andras Dinnyes, HU-Godollo |
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20 min | Alternative research methods for challenging disease: human iPS derived Parkinson’s-on-chip Julie Rosser, AT-Vienna |
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20 min | A new approach for animal free carcinogenicity testing using MN as biomarker (PMNvit) Bastian Niklas Hölzel, DE-Aarbergen |
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15 min | Carp Stem Cells Growth on Chorioallantoic Membrane of Fertilized Hen's Egg Mahmoud Galal, EG-Cairo |
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15 min | Modeling sex differences in vitro Judith Lechner, AT-Innsbruck |
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15:30-16:00 | Coffee break and posters | |
Scientific sessions 16:00-17:30 | ||
HALL 1 |
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1.5 3D Models & Multi-Organ-Chips (MOC), Human-Organ-Chips (HOC) V - Future Applications Chairs: Helena Kandarova, SK-Bratislava, and Jochen Kühnl, DE-Hamburg (the topic 3D Models & Multi-Organ Chips (MOC), Human-Organ-Chips (HOC) is sponsored by the Lush Prize) |
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20 min | Tomorrow today: organ-on-a-chip advances towards clinically relevant pharmaceutical and medical in vitro models Peter Ertl, AT-Vienna |
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15 min | Microphysiological flux balance platform unravels the dynamics of drug induced steatosis Muneef Ayyash, IL-Jerusalem |
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15 min | Importance of computational modelling in the design of Organ on a Chip Devices Bhumika Singh, GB-Rotherham |
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12 min | Impact of Spheroidal Age on Drug Toxicity and Diffusivity Christoph Eilenberger, AT-Vienna |
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15 min | 3D Models and Multi-Organ-Chips: Scaffold-free 3D tissue models – from static to microphysiological applications Oliver Frei, CH-Schlieren |
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13 min | General Discussion | |
HALL 2 |
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7.2 Disease Models Using HUMAN Cells, Tissues and Organs - Lung & Infection Chairs: Stefan Hippenstiel, DE-Berlin, and Samuel Constant, CH-Plan-les-Ouates |
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20 min | A human lung ex vivo infection model Stefan Hippenstiel, DE-Berlin |
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15 min | Human cell- and tissue-based models of the lungs in state of health and disease Nicole Schneider-Daum, DE-Saarbrücken |
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12 min | Modeling respiratory bacterial infections using in vitro human airway epithelia Samual Constant, CH-Plan-les-Ouates |
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15 min | 3D Epithelial Culture Model to Study Chlamydia Infection Munir Al-Zeer, DE-Berlin |
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15 min | hAELVi cells as an in vitro inflammation model Julia Katharina Metz, DE-Saarbrücken |
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13 min | General discussion | |
HALL 3 |
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16.1 Specific Endpoints of Toxicity I Chairs: Rodger Curren, US-Gaithersburg, and Robert Landsiedel, DE-Ludwigshafen |
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20 min | Evaluation of retinoic acid receptor alpha (RARα) interaction of chemicals by combining two techniques to a new screening approach Barbara Birk, DE-Ludwigshafen |
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20 min | Non-animal methods for skin sensitisation testing - is there really a need for integrated testing strategies? David Roberts, GB-Liverpool |
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20 min | Pre-validation of an Acute Inhalation Toxicity Test Using the EpiAirway In Vitro Human Airway Model Silvia Letasiova, SK-Bratislava |
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15 min | The added value of the 90-day repeated dose test for substances of low (sub) acute toxicity for REACH purposes Katy Taylor, GB-London |
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15 min | General discussion | |
Round table III 17:35-18:35 | ||
HALL 1 | ||
Applying human 3D models and Multi-Organ-Chips (MOCs) in Industry | ||
Moderator Winfried Neuhaus, AIT, AT-Vienna Panelists Samuel Constant, Epithelix & Oncotheis, CH-Plan-les-Ouates Helena Kandarova, MatTek, SK-Bratislava (to be confirmed) Jochen Kuehnl, Beiersdorf, DE-Hamburg Robert Landsiedel, BASF, DE-Ludwigshafen Peter Ertl, Vienna University of Technology, AT-Vienna |
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Poster session II 18:35-20:00 | ||
POSTER HALL |
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Poster session with coffee Survey of the posters with presence of the authors |
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20.15 | Departure to the Social Evening | |
20.30 | Social Evening | |
Wednesday, 26 September 2018 | ||
Keynote lecture 09:00-09:30 | ||
HALL 1 |
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30 min | Having a Successful Career in in vitro Toxicology: Pillars of Success Helena Kandarova Executive Director, MatTek IVLSL (In Vitro Life Science Laboratories), SK-Bratislava |
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Scientific sessions 09:35-11:05 | ||
HALL 1 |
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20.1 'Young Scientists' session I Chairs: Christian Zoschke, DE-Berlin, and Kristina Wagner, DE-Neubiberg |
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12 min | The hen’s egg test on the chick area vasculosa (HET-CAV) as a test system to evaluate the antimicrobial activity of drugs and formulations Paul Warncke, DE-Jena awarded with the YSTA 2018 |
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12 min | Comparison of Breathing Patterns for Aerosol Inhalation Using an Electro-mechanical Lung Simulator Richard Paštěka, AT-Vienna awarded with the YSTA 2018 |
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12 min | Off-target effects of novel purine-analog phosphonates for anti-cancer therapy Christian Zoschke, DE-Berlin |
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12 min | A dynamic model of the alveolar interface for the study of aerosol deposition Roberta Nossa, IT-Pisa awarded with the YSTA 2018 |
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12 min | Human buffy-coat derived platelet lysate: comparison of single-patient and pooled units for the cultivation of different human cell lines Michelle Hesler, DE-Sulzbach awarded with the YSTA 2018 awarded with the Young Scientist Best Oral Award 2018 for the best oral presentation |
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12 min | Organ-on-a-chip meets traction force microscopy: In situ characterization of forces in 3D micro-tissues Stefanie Fuchs, DE-Stuttgart awarded with the YSTA 2018 |
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18 min | General discussion | |
HALL 2 |
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14.3 Refinement & Reduction III - Increase Transparency and Use Existing Infrastructures to Reduce the Lab Animal Usage Chairs: Christa Thöne-Reineke, DE-Berlin, and Christiane Hohensee, DE-Aachen |
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20 min | Sharing is Caring – Update on innovative approaches to share organs and tissues to reduce the lab animal usage Annemarie Lang, DE-Berlin |
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20 min | The elephant in the room: PREPARE before you ARRIVE Adrian Smith, NO-Oslo |
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20 min | It´s time to rethink: learn from negative results in animal based research! Critical Incident Reporting System in Laboratory Animal Science CIRS-LAS.DE Sabine Bischoff, DE-Jena |
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15 min | Promoting transparency in preclinical research: preregistration of preclinical studies on www.preclinicaltrials.eu Mira van der Naald, NL-Utrecht |
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15 min | The Horse as Model for Osteoarthritis Research – Research Tools vs. Stakeholders Annemarie Lang, DE-Berlin |
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HALL 3 |
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16.2 Specific Endpoints of Toxicity II Chairs: Dagmar Jirová, CZ-Prague |
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20 min | Impedance spectroscopy as a method to discriminate between all GHS categories for eye irritation in vitro Christian Lotz, DE-Würzburg |
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20 min | Integrating Knowledge Of Carcinogenicity Adverse Outcome Pathways (AOPs) With Experimental Data Steven Kane, GB-Leeds |
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20 min | In vitro methods for identifying substances with endocrine disruption potential Marketa Dvorakova, CZ-Prague |
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15 min | Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate proliferation of granulosa tumor via IGF1R - 3D cell culture model Justyna Gogola, PL-Krakow awarded with the YSTA 2018 |
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15 min | General discussion | |
11:05-11:35 | Coffee break and posters | |
Scientific sessions 11:35-13:05 | ||
HALL 1 | ||
20.2 'Young Scientists' session II Chairs: Dominik Rünzler, AT-Vienna, and Winfried Neuhaus, AT-Vienna |
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12 min | Co-Cultivation of myofibroblasts and adipocytes provides new insights into hypertrophic scar regeneration Katharina Hörst, DE-Berlin awarded with the YSTA 2018 awarded with the Young Scientist Best Oral Award 2018 for the third best oral presentation |
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12 min | Development of advancing human 3D trabecular meshwork models to assess onset of Glaucoma Sara Tirendi, IT-Genova awarded with the YSTA 2018 |
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12 min | 3Rs in Education - Systematical Evaluation of Simulators for Rats and Mice Melanie Humpenöder, DE-Berlin awarded with the YSTA 2018 |
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12 min | Bioinformatics analysis of IPS cell data to elucidate mechanisms of actions of nephrotoxins Pranika Singh, CH-Basel |
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12 min | SimulRator – Manufacturing a 3D-printed simulator of the rat for laboratory animal training courses Giuliano Mario Corte, DE-Berlin awarded with the YSTA 2018 |
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12 min | Chronic lymphocytic leukemia cells as an in vitro model in preclinical drug evaluation Tijana Markovic, SI-Ljubljana |
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18 min | General discussion | |
HALL 2 | ||
7.3 Disease Models Using HUMAN Cells, Tissues and Organs - Skin Tumor Models Chairs: Monika Schäfer-Korting, DE-Berlin, and Stefanie Schindler, CH-Bern |
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20 min | Normal human skin and atopic dermatitis models – penetration and efficacy of topical glucocorticoids Monika Schäfer-Korting, DE-Berlin |
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20 min | Human cell-based tumor microenvironment models for improved preclinical drug development Christian Zoschke, DE-Berlin |
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20 min | 3D melanoma skin models: unravelling the effects of the basal membrane and sub-populations of fibroblasts in tumour progression and invasion Abdoel El Ghalbzouri, NL-Leiden |
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15 min | Unusual, innovative, and close to in-vivo: MUG-Mel1 and MUG-Mel2 melanoma cell lines for drug development Beate Rinner, AT-Graz |
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15 min | General discussion | |
Closing Remarks13:10-13:30 | ||
HALL 1 | ||
Closing Remarks |
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Wednesday, 26 September 2018 |
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13:45-18:00 |
Day one open to all participants of the EUSAAT 2018 Congress, registration required, for details click HERE |
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Thursday, 27 September 2018 |
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08:30-11:00 |
Day two open to all participants of the EUSAAT 2018 Congress, registration required, for details click HERE |