Programm
Abstracts of lectures and posters: click here(pdf, 1,77 MB; all which were submitted in time; published in Altex 27, Suppl. 2/10) |
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Wednesday, September 1st 2010 |
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12:00-19:00 | Registration open |
14:00-19:00 |
Pre-Congress Meetings |
AXLR8 - '21st Century Approaches to Toxicology'
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funded by the EU FP6 & FP7 program on “Alternative Testing Strategies” | |
14:00-14:05 | Welcome & Opening Remarks Chairperson (Troy Seidle, Humane Society International, UK) |
14:05-14:30 | Horst Spielmann, Freie Universität Berlin, DE The EU FP7 Project "AXLR8" |
14:30-15:00 | Carl-Frederik Mandenius, Linköping University, SE The EU FP6 Project "VITROCELLOMICS" |
15:00-15:30 | Erwin Roggen, Novozymes, DK EU FP6 Project Sens-it-iv |
15:30-15:45 | Coffee break |
15:45-16:15 | Walter Pfaller, Innsbruck Medical University, AT The EU FP7 Project "PREDICT-IV" |
16:15-16:45 | Imran Shah, Environmental Protection Agency, US The US ToxCast & Tox21 Programs |
16:45-17:30 | Panel Discussion Chairperson (Greet Schoeters, VITO-CARDAM, BE) |
17:30 | Close |
This event is free to attend, but pre-registration is encouraged. Register online at AXLR8.eu/workshops. |
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Workshop - Presentation of search engines with hands-on trials on PC terminals |
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14:00-14:45 | Daniel Brunner, Linz, A The online database for serum-free cell culture media GROUP A |
15:00-15:45 | Daniel Brunner, Linz, A The online database for serum-free cell culture media GROUP B |
16:00-17:20 | Barbara Grune, BfR, Berlin, D, Ursula G. Sauer, Scientific Consultancy - Animal Welfare, Neubiberg, D, Liliana Barrio-Alvers, Transinsight GmbH, Dresden, D The Go3R Search Engine GROUP C |
17:30-18:50 | Barbara Grune, BfR, Berlin, D, Ursula G. Sauer, Scientific Consultancy - Animal Welfare, Neubiberg, D, Liliana Barrio-Alvers, Transinsight GmbH, Dresden, D The Go3R Search Engine GROUP D |
This workshop is free to attend, but pre-registration is required. Each group is limited up to 18 participants. |
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16:00-18:00 |
Pre-Congress Symposium on Serum-free Cell Culture
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Chairs: Gerhard Gstraunthaler, A, and Jan Van der Valk, NL | |
Agenda 1. Workshop Report (Toxicol. in Vitro 2010): |
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This symposium is free to attend, but pre-registration is required. Please register via email: j.vandervalk@uu.nl | |
13:00-17:00 | Build-up of exhibition |
13:00-17:00 | Poster area accessible |
19:00-22:00 |
Welcome Evening - Get Together |
19:00-19:30 | Opening Lecture Walter Pfaller, Innsbruck Medical University, A Lessons learned from 25 years of nephrotoxicity testing in vitro |
19:30-22:00 | Get Together Party |
congress sponsor |
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Thursday, September 2nd 2010 |
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07:30-09:00 | Registration |
09:00-09:15 | Welcome Addresses |
Session I - Legal, Ethical and Policy Topics Regarding Alternatives |
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Chairs: Emily McIvor, UK, and Alois Haslinger, A | |
09:15-09:45 | State of the art lecture Susanna Louhimies, EU - DG Environment, B Current status of the revision process regarding the Directive 609/86 EEC |
oral presentations |
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09:45-10:00 | Irmela Ruhdel, D New EU Directive on the protection of laboratory animals: animal welfare perspective |
10:00-10:15 | Kristie Sullivan, USA A qualitative and quantitative examination of the impact of chemical regulation legislation on the field of toxicity testing |
10:15-10:30 | Hans Steinkellner, I Human Health Risk Assessment of Pesticides - Novel Approaches explored by EFSA’s PPR Panel |
10:30-10:45 | Dagmar Jirova, CZ Alternative methods as an integral part of in-market control on cosmetics in the Czech Republic |
10:45-11:15 | Coffee break and posters |
Session II - Metabolism and Toxicokinetics |
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Chairs: Katrin Zeilinger, D, and Mathieu Vinken, B |
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11:15-11:45 | State of the art lecture Mia Emgard, Cellartis AB, S Human pluripotent stem cells and their derivatives in assay for chemical risk assessment |
oral presentations |
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11:45-12:00 | Katrin Zeilinger, D Human liver cell cultivation in a miniaturized 3D bioreactor system for in vitro studies on hepatic drug toxicity |
12:00-12:15 | Jean-Paul Derouette, CH An in vivo like expression pattern of CYP450 enzymes found in a 3D in vitro model of the human airway epithelium - MucilAir™ |
12:15-12:30 | Jennifer Bolleyn, B Effect of Trichostatin A on miR-122 expression in primary hepatocyte cultures |
12:30-12:45 | Anett Ullrich, D Human hepatocyte cultures allow repeated application of drugs resulting in repeatable effects on hepatocellular metabolism |
12:45-14:00 | Lunch (business lunch to be served at the congress venue) |
13:00-14:00 | Business Lunch - ESTIV Students Session |
Chair: Maria Laura Scarino, I | |
Session III - Skin / Sensitisation and Eye Irritation |
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Chairs: Nathalie Alépée, F, and Chantra Eskes, NL |
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14:00-14:30 | State of the art lecture Patrick Amcoff, OECD, F Skin toxicity and regulations aspects |
oral presentations |
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14:30-14:45 | Stefanie Schoepe, D Identification of novel in vitro test systems for the determination of glucocorticoid receptor-ligand induced skin atrophy |
14:45-15:00 | Guenther Weindl, D Models of localized Candida infections based on in vitro reconstituted human epithelia |
15:00-15:15 | Marisa Meloni, I In vitro safety assessment of cosmetic products: investigation of new endpoints for eye irritation |
15:15-15:30 | Sebastian Hoffmann, D ECVAM prevalidation study on skin sensitisation alternatives: update on progress |
15:30-15:45 | Nathalie Lambrechts, B Assessment of chemical skin sensitizing potency by an in vitro assay based on human dendritic cells |
15:45-16:00 | Andreas Natsch, D Prediction of skin sensitizers by combining a high-throughput keratinocyte-based reporter gene assay with peptide reactivity measurements |
16:00-16:15 | Silvia Martinozzi Teissier, F Development, refinement and combination of in vitro assays to hurdle skin sensitization complexity |
Session IV - Good Cell Culture Practice |
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Chair: Gerhard Gstraunthaler, A, and Rodger Curren, USA |
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16:15-16:45 | State of the art lecture Wilhelm Dirks, DSMZ, D STR DNA Typing: Intra- and Interspecies Cross-Contamination Detection of Human Cell Lines |
16:45-17:00 | Jan van der Valk, NL Improving in vitro methods by developing and using defined culture media |
17:00-17:15 | Sabrina Ehnert, D Use of autologous serum improves yield and quality of neohepatocytes for in vitro toxicity testing |
17:15-19:00 |
Poster session I |
with coffee & regarding topics of session I to IV survey of the posters with presence of the authors |
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Chairs: M. Liebsch, D, Pilar Prieto, I, Irmela Ruhdel, D, Paul Jennings, A, Jan Van der Valk, NL |
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list of posters (or as pdf: in alphabetical order (pdf, 242 KB) or sorted by session-numbers (pdf, 238 KB)) | |
19:30-20:00 |
Annual General Assembly of EUSAAT (invitation EUSAAT Annual General Assembly 2010) |
Friday, September 3rd 2010 |
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Session V - Acute and Long Term Toxicity - part A |
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Chairs: Greet Schoeters, B, and Dagmar Jirova, CZ |
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08:30-09:00 | State of the art lecture Paul Jennings, Innsbruck Medical University, A The role of the Nrf2 pathway in nephrotoxicity |
09:00-09:15 | Hasso Seibert, D Peroxide-induced oxidative stress and cell death in C6 astroglioma cells |
09:15-09:30 | Samuel Constant, CH Assessment of acute, long term and chronic respiratory toxicity using a long shelf life 3D model of the human airway epithelium |
09:30-09:45 | Ralph Pirow, D Testing of the toxicity of volatile compounds on human lung cells using the Air/Liquid Interface (ALI) culturing and exposure technique: a prevalidation study |
09:45-10:00 | Annette Kopp-Schneider, D Statistical Analysis of the AcuteTox data aimed to identify an in vitro testing strategy for prediction of acute oral toxicity |
10:00-10:30 | Coffee break and posters |
Session VI - Acute and Long Term Toxicity - part B |
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Chairs: Eva-Maria Collnot, D, and Klaus R. Schröder, A |
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oral presentations |
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10:30-10:45 | Seyoum Ayehunie, USA EpiVaginal tissue model for preclinical toxicity screening of chemicals/formulations following single or repeat applications |
10:45-11:00 | Sara Lindén, S In vitro gastrointestinal mucosal surfaces for studying host-pathogen interactions at the mucosal interphase |
11:00-11:15 | Anja Wilmes, A Transcriptomic, proteomic and metabolomic alterations in RPTEC/TERT1 cells in response to Cyclosporine A |
11:15-11:30 | Albrecht Poth, D In vitro cell transformation assays - Their use in safety and risk assessment |
Special Session on Antibody Production |
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sponsored by the Dr Hadwen Trust (UK) | |
Chair: Alison Gray, UK, Sebastien Farnaud,UK | |
oral presentations |
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11:30-11:45 | AS Kang, UK Recombinant antibodies. Past, Present and Future |
11:45-12:00 | Dong Barraclouogh, UK Exploitation of potential aptamer technology to replace animal antibody against human tumour biomarkers |
12:00-12:15 | Mingyue He, UK Generation of antibodies in vitro: No living cells required |
12:15-12:30 | Discussion |
12:30-14:00 | Lunch (business lunch to be served at the congress venue) |
Session VII - Nanotoxicology |
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This session is sponsored by Animalfree Research, CH-Zurich |
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Welcome Address: Sabine Umbricht-Vonlanthen, Director Animalfree Research, CH-Zurich |
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Chairs: Ursula G. Sauer, D, and Robert Landsiedel, D |
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14:00-14:20 | State of the art lecture: Robert Landsiedel, BASF, D The use of alternative methods for toxicity testing of nanomaterials |
oral presentations |
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14:20-14:35 | Mario Götz, D The role of alternative test methods in nanotoxicology |
14:35-14:50 | Christina Brandenberger, CH Air liquid exposure of gold nanoparticles to study effects, uptake and intracellular distribution in a human 3D epithelial airway model |
14:50-15:05 | Eva-Maria Collnot, D In vitro model of inflammatory bowel disease for drug formulation testing and screening |
15:05-15:20 | Anne Kahru, EE High-to-medium-throughput evaluation of the ecotoxicity and toxicological profiling of synthetic nanoparticles |
15:20-16:00 | Round Table – Towards non-animal testing strategies in nano-toxicology – what needs to be done and who will do it? |
Chair and introductory note: Ursula G. Sauer, D |
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Participants: Robert Landsiedel, D, Mario Götz, D, Christina Brandenberger, CH, Eva-Maria Collnot, D, Anne Kahru, EE, Cyrille Krul, NL, Eleonore Fröhlich, A |
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Closing remarks of this session: Stefanie Schindler, Animalfree Research, CH |
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16:00-18:00 |
Postersession II |
with coffee & regarding topics of session V to IX survey of the posters with presence of the authors |
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Chairs: M. Liebsch, D, Pilar Prieto, I, Irmela Ruhdel, D, Paul Jennings, A, Jan Van der Valk, NL |
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list of posters (or as pdf: in alphabetical order (pdf, 242 KB) or sorted by session-numbers (pdf, 238 KB)) | |
17:30-18:30 |
General Assembly ESTIV 2010 (invitation ESTIV General Assembly 2010) |
19:00 |
Departure to the Social Evening |
19:30 |
Social Evening - Award Ceremonies |
"Dieter Lütticken Award (DLA) To Stimulate Reduction Of Animal Testing" awarded by the "Intervet Schering-Plough Animal Health Foundation" |
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Award of the Doerenkamp-Zbinden Foundation | |
Saturday, September 4th 2010 |
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Session VIII - Reproductive Toxicology and Stem Cells |
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Chairs: Horst Spielmann, D, Kristie Sullivan, US |
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09:00-09:30 | State of the art lecture: Horst Spielmann, FU Berlin, D The way forward in reproductive/developmental toxicology |
oral presentations |
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09:30-09:45 | Katrin Hayess, D Mouse embryonic stem cells in developmental neurotoxicity testing: aiming at higher throughput and specificity |
09:45-10:00 | Pablo Steinberg, D The coupling of a metabolic activation system (primary hepatocytes) to the murine embryonic stem cell test expans its use in reproductive toxicity testing |
10:00-10:15 | Gabriela G. Cezar, USA Predicting Developmental Toxicity With Human Embryonic Stem Cells and Metabolomics |
10:15-10:30 | Sarah Snykers, B Optimised 1D and 3D isolation and expansion of multipotent human adipose–derived stem cells |
10:30-11:00 | Coffee break and posters |
Session IX - New Developments and Novel Methods |
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Chairs: Erwin Roggen, DK and Thomas Hartung, USA |
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11:00-11:30 | State of the art lecture: Thomas Hartung, CAAT, US Lessons learned from alternative methods and their validation for a new toxicology in the 21st century |
oral presentations |
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11:30-11:45 | Rodger Curren, USA An in vitro ocular testing strategy for US EPA registration of anti-microbial cleaning products |
11:45-12:00 | Jacqueline Pusch, D Establishment of a 3D intestinal tissue equivalent in vitro |
12:00-12:15 | Tine Hectors, B Evaluation of in vitro models for investigation of endocrine disruptive effects on insulin metabolism using omics |
12:15-12:30 | Terry Riss, USA Multiplexing Various In Vitro Toxicity Assays for High Throughput Screening |
12:30-12:45 | Kerstin Reisinger, D The Hen´s egg micronucleustest (HET-MN): successful intra- and interlaboratory reproducibility study |
12:45-13:00 | Martin Leonard, IRL Toxicity Profiling of Nephrotoxins in the Human Proximal Tubular RPTEC-TERT1 Cell Line: Influence of Hypoxia |
13:00-13:15 | Stefan Schildknecht, D Application of human dopaminergic neurons for toxicity testing |
13:15-13:45 |
Award Ceremonies |
Poster awards by ALTEX, EUSAAT and ESTIV |
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13:45-14:00 |
Concluding Remarks |
14:00 |
End of the Congress |
Farewell sandwiches, coffee & tea |
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Additional information for all speakers: Please find here the guidelines for submitting manuscripts for the ESTIV/EUSAAT 2010 proceedings, to be published in Toxicology in Vitro - download pdf (75 KB) |