Program by days
(v. 17.09.2015)
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Sunday, 20 September 2015 | ||
Opening 13:00-13:45 | ||
HALL 1 | ||
13:00-13:10 | Welcome addresses | |
13:10-13:15 | Signing of the co-operation agreement between EUSAAT and JSAAE - the Japanese Society for Alternatives to Animal Experiments | |
13:15-13:45 | Opening lecture: Directive 2010/63/EU - achievements and challenges Susanna Louhimies, BE-Brussels |
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Scientific sessions 13:45-15:15 | ||
18.1: 3Rs in Academia & Education I Chairs: Ellen Fritsche, DE-Düsseldorf & Monika Schäfer-Korting, DE-Berlin |
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HALL 3 |
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13:45-14:03 | The Berlin-Brandenburg Research Platform BB3R and integrated graduate school Monika Schäfer-Korting, DE-Berlin |
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14:03-14:21 | CERST-NRW: a German state government of North Rhine Westphalia-funded initiative for the development of alternative methods to animal testing Ellen Fritsche, DE-Düsseldorf |
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14:21-14:39 | Teaching alternative methods in toxicology in veterinary science Francesca Caloni, IT-Milano |
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14:39-14:57 | Romanian Center for Alternative Test Methods (ROCAM) – a newly established 3Rs Center to promote and support the alternative methods field in Romania Lucian Farcal, RO-Cluj-Napoca |
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14:57-15:15 | CAAT-Europe and knowledge exchange on the progress of the 3Rs and research methods Marcel Leist, DE-Konstanz |
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9.1: Skin Sensitization I Chairs: Robert Landsiedel, DE-Ludwigshafen & Joao Barroso, IT-Ispra |
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HALL 1 |
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13:45-14:15 | Outlook on currently available non-animal test methods for skin sensitization testing Daniel Urbisch, DE-Ludwigshafen |
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14:15-14:45 | Reconstituted Human Epidermis Models and IL-18 Levels for Identification and Potency Ranking of Skin Sensitizers: Identification of Critical Steps and Harmonization of Existing Protocols for the Purpose of Validation Erwin Roggen, DK-Bagsvaerd shifted to Monday, session 10.2. |
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14:45-15:15 | Evaluating non-animal methods for identifying skin sensitisation hazards: A Bayesian value of information analysis Maria Leontaridou, DE-Ludwigshafen |
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15:15-16:00 | Coffee break and posters | |
Scientific sessions 16:00-17:30 | ||
12.1: Disease Models I: CRISPR/Cas Chairs: Horst Spielmann, DE-Berlin & Malte Spielmann, DE-Berlin |
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HALL 1 |
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16:00-16:10 | Scientific and animal welfare issues surrounding the new CRISPR/Cas-9 approach to produce transgenic animals and advanced in vitro disease models Horst Spielmann, DE-Berlin |
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16:10-16:40 | CRISPR/Cas-induced structural variants Malte Spielmann, DE-Berlin |
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16:40-17:05 | Paving the way to a novel analysis platform to study human diseases Saniye Sprenger, DE-Berlin |
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17:05-17:30 | Modeling the air-blood-barrier in state of disease – challenges and perspectives Marius Hittinger, DE-Saarbrücken |
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3.1: 3D Models I Chairs: Ellen Fritsche, DE-Düsseldorf & Tzutzuy Ramirez, DE-Ludwigshafen |
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HALL 3 | ||
16:00-16:18 | Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events Ellen Fritsche, DE-Düsseldorf |
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16:18-16:36 | Stem-cell based in vitro models to study human CNS pathophysiology Zeynab Nayernia, CH-Geneva |
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16:36-16:54 | The use of the 'Neurosphere-Assay’ to study specific disturbances on FGF-2 function during neurodevelopment Marta Barenys, DE-Düsseldorf |
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16:54-17:12 | Assessment of the predictivity of neuronal networks coped to microelectrode arrays for identification of neurotoxicants Tzutzuy Ramirez, DE-Ludwigshafen |
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17:12-17:30 | Advances in in vitro testing: the route to replace animal testing Stella Homer, UK-Rotherham |
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18:00-22:00 | Welcome reception (at the congress venue) | |
paid advertising |
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Monday, 21 September 2015 | ||
Scientific sessions 09:00-10:30 | ||
1.1: Multi-Organ-Chips I Chairs: Uwe Marx, DE-Berlin & Dmitry Sakharov, RU-Moscow |
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HALL 1 |
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09:00-09:30 | Six organ chip for substance toxicity testing using Homunculus platform Dmitry Sakharov, RU-Moscow |
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09:30-10:00 | Pro-drug activation in a dynamic microfluidic systems interconnecting liver and tumor micro-tissues" Jens Kelm, CH-Schlieren |
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10:00-10:30 | Mimicking the cyclic mechanical stress of the lung parenchyma in a breathing lung-on-chip Janick Stucki, CH-Bern |
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2: Stem Cells Chairs: James Adjaye, DE-Düsseldorf & Jürgen Hescheler, DE-Köln |
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HALL 3 | ||
09:00-09:18 | Geometrically confined cell differentiation and migration model for human teratogen detection Jiangwa Xing, SG-Singapore |
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09:18-09:36 | Quantitative data on toxicant classification derived from transcriptomics studies of stem cell development Marcel Leist, DE-Konstanz |
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09:36-09:54 | Vascular-like network enhances structural and functional maturation of human pluripotent stem sell derived cardiomyocytes in cardiovascular construct Hanna Vuorenpää, FI-Tampere |
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09:54-10:12 | Human induced pluripotent stem cells as tools for studying the etiology of Non Alcoholic Fatty Liver Disease James Adjaye, DE-Düsseldorf |
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10:12-10:30 | Differentiated human skin-derived stem cells as a novel cell source for in vitro screening of drug-induced liver injury (DILI) Vera Rogiers, BE-Brussels |
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10.2: Efficacy & Safety Testing II - Biologicals and Vaccines Chairs: Emina Wild, DE-Langen & Sebastian Hoffmann, DE-Paderborn |
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HALL 2 |
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09:00-09:18 | In vitro assays for the potency determination of botulinum neurotoxin serotypes A and B Emina Wild, DE-Langen |
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09:18-09:36 | Avian encephalomyelitis live vaccines - alternative methods for batch virus titration Lena Rimpel, DE-Langen |
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09:36-09:54 | Reconstituted Human Epidermis Models and IL-18 Levels for Identification and Potency Ranking of Skin Sensitizers: Identification of Critical Steps and Harmonization of Existing Protocols for the Purpose of Validation Erwin Roggen, DK-Bagsvaerd |
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09:54-10:12 | Pro- and pre-hapten mechanisms in skin sensitization David Roberts, UK-Liverpool |
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10:12-10:30 | LLNA variability: an essential ingredient for a comprehensive assessment of non-animal skin sensitisation test methods and strategies Sebastian Hoffmann, DE-Paderborn |
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10:30-11:00 | Coffee break and posters | |
Scientific sessions 11:00-12:30 | ||
5.2: QSAR & Read Across II - QSAR Chairs: Karel de Raat, FI-Helsinki & Matthias Herzler, DE-Berlin |
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HALL 3 | ||
11:00-11:18 | Use of (Q)SARs under REACH - perspective of a regulator Matthias Herzler, DE-Berlin |
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11:18-11:36 | Application of in silico methods for predictions of different toxicological endpoints Malgorzata Drwal, DE-Berlin |
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11:36-11:54 | QsarDB: solution strategy for efficient use of QSAR models Uko Maran, EE-Tartu |
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11:54-12:12 | The Future of the QSAR Toolbox: moving to less uncertainty in predictive toxicology Romualdo Benigni, IT-Roma |
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12:12-12:30 | Weighted gene co-expression network analysis to characterize drug induced cardiotoxicity Jufeng Wang, CN-Beijing |
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11: Nano-Toxicology Chairs: Natalie Burden, UK-London & Robert Landsiedel, DE-Ludwigshafen |
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HALL 1 |
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11:00-11:15 | Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long term opportunities? Natalie Burden, UK-London |
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11:15-11:30 | NanoSafety research and its challenges! Peter Wick, CH-St. Gallen |
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11:30-11:45 | Cytotoxic and immunological effects of engineered nanomaterials Marika Mannerstrom, FI-Tampere |
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11:45-11:55 | Adressing inflammatory parameters of the intestinal mucosa: From the mouse to the test tube Benno Weigmann, DE-Erlangen |
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11:55-12:05 | An advanced 3D human epithelial airway model to study the biokinetics of aerosolized biomedical nanoparticles after repeated exposures Savvina Chortarea, CH-Fribourg |
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12:05-12:15 | Towards the prediction of nanoparticle-induced inhalation toxicity: Evaluation of an in vitro macrophage assay Martin Wiemann, DE-Münster |
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12:15-12:30 | A decision-making framework for the grouping and testing of nanomaterials Robert Landsiedel, DE-Ludwigshafen |
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12.2: Disease Models II: hiPSC Chairs: Manfred Liebsch, DE-Königs Wusterhausen & Justine Miller, US-Rensselaer NY |
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HALL 2 |
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11:00-11:20 | Reconstructed human skin pioneers the implementation of diversity into preclinical testing in vitro Monika Schäfer-Korting, DE-Berlin |
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11:20-11:40 | Human stem-cell based functional neuronal in vitro disease models Susanna Narkilahti, FI-Tampere |
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11:40-12:00 | Alzheimer's disease research in the 21st century: the shift towards a new paradigm Francesca Pistollato, US-Washington DC |
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12:00-12:20 | In vitro hiPSC-based modeling of late-onset disease using progerin-induced aging Justine Miller, US-Rensselaer NY |
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12:30-13:30 | Business lunch (to be served at the congress venue) and posters |
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Scientific sessions 13:30-15:00 | ||
4: International Progress in 3Rs' Research & Global Cooperation on Implementing the 3Rs Chairs: Hajime Kojima, JP-Tokyo & Troy Seidle, CND-Toronto |
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HALL 2 |
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13:30-13:48 | Beyond Europe: Accelerating regulatory uptake and use of 3R best practices globally Troy Seidle, CA-Toronto |
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13:48-14:06 | EPAA - 10 years of progress and more to do Renate Weissenhorn, BE-Brussels |
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14:06-14:24 | The Asian Congress on Alternatives and Animal Use in the Life Sciences 2016 Hajime Kojima, JP-Tokyo |
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14:24-14:42 | Transatlantic collaboration of Cosmetics Europe with NICEATM/ILS to assess and develop strategy for skin sensitisation safety assessment without animal testing Sebastian Hoffmann, DE-Paderborn |
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14:42-15:00 | Decision Algorithm for 3R (Refine, Reduce, Replace) Programs - a case study in vaccines Iwona Wilk-Zasadna, CH-Basel |
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6: Risk Assessment Based on the AOP Concept Chairs: Ellen Fritsche, DE-Duesseldorf & Anna Bal-Price, I-Ispra |
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HALL 3 |
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13:30-13:48 | MIEs – the gateways to pathway prediction Paul Russell, UK-Shambrook |
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13:48-14:06 | Integration of the epidemiological data with the experimental toxicity studies on pesticides; use of the AOP framework for the definition of biological plausibility Andrea Terron, IT-Parma |
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14:06-14:24 | Characterization of the effects of epigallocatechin gallate (EGCG) exposure during neurodevelopment within the AOP concept Marta Barenys, DE-Düsseldorf |
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14:24-14:42 | Applying Adverse Outcome Pathways to support Integrated Approaches to Testing and Assessment (IATA) João Barroso, IT-Ispra |
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14:42-15:00 | Adverse Outcome Pathway Knowledge Base: A crowdsourcing tool to add value to existing information on Alternative Methods results Clemens Wittwehr, IT-Ispra |
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14: EU Directive 2010/63/EU on the Protection of Animals Used for Scientific Purposes Chairs: Herman Koeter, NL-Den Haag & Susanna Louhimies, BE-Brussels |
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HALL 1 | ||
13:30-13:55 | Directive 2010/63/EU: five years after its adoption Herman Koeter, NL-Den Haag |
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13:55-14:15 | Non-technical summaries - a review of EU member states efforts so far Katy Taylor, UK-London |
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14:15-14:30 | Different concepts of committees in EU member states, to support the competent authorities performing the project evaluation according to Directive 2010/63/EU Norbert Alzmann, AT-Vienna |
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14:30-14:45 | The Role of the National Committee in Germany - Severity Assessment of Genetically Altered Animals Bettina Bert, DE-Berlin |
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14:45-15:00 | Legal issues in the work of the German National Committee: an overview Justyna Chmielewska, DE-Berlin |
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paid advertising |
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15:00-15:30 | Coffee break and posters | |
Scientific sessions 15:30-17:00 | ||
1.2: Multi-Organ-Chips II Chairs: Dmitry Sakharov, RU-Moscow & Uwe Marx, DE-Berlin |
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HALL 1 | ||
15:30-16:00 | Microfluidic in vitro platform for parallel human multi-tissue interaction studies Jin-Young Kim, CH-Zurich |
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16:00-16:30 | Emulating the human vasculature in a multi-organ-chip platform Tobias Hasenberg, DE-Berlin |
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16:30-17:00 | Cryopreserved human hepatocytes and IdMOC experimental system for the evaluation of human drug properties Albert Li, US-Columbia MD |
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15.1: Ethics & Legal Issues I Chairs: Herwig Grimm, AT-Vienna & Emily McIvor, UK-Seaton |
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HALL 3 |
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15:30-15:50 | Pain for Profit. Can monetary reasons justify animal research ethically? Herwig Grimm, AT-Vienna |
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15:50-16:10 | Evaluation of the scientific validity of animal experiments in Switzerland Lucile Vogt, CH-Bern |
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16:10-16:30 | Implementing the 3Rs: turning words into action Emily McIvor, UK-Seaton |
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18.2: 3Rs in Academia & Education II Chairs: Marcel Leist, DE-Konstanz & Candida Nastrucci, IT-Rome |
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HALL 2 |
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15:30-15:43 | Reboot3R - Design Thinking Workshops for scientists to constructively find ways to apply 3Rs within their own career Cecilia Hilmer, DE-Berlin |
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15:43-15:56 | Animal Research: critical, challenging & creative thinking about the 3Rs Juliet Dukes, UK-Southwater |
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15:56-16:09 | A Course in Alternatives: focus on replacement and non-animal methods Candida Nastrucci, IT-Rome |
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16:09-16:22 | Follow-up on 2013 EUSAAT’s Congress and its impact for Sri Lankan scientific community in 3Rs Mangala Gunatilake, LK-Colombo |
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16:22-16:35 | Improving animal welfare through competence: The EUPRIM-Net education and training programs Valeska Marija Stephan, DE-Göttingen |
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16:35-16:48 | Refinement of welfare through application of a quantitative system for assessment of lifetime experience Michael Dennis, UK-Salisbury |
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16:48-17:01 | Journal policies on animal use – current landscape and future directions Nuno Henrique Franco, PT-Porto |
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17:00-19:00 | Poster session I with coffee - authors present Survey of the posters with presence of the authors |
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19:00-20:30 | Annual General Assembly of EUSAAT (members only) | |
Tuesday, 22 September 2015 | ||
Scientific sessions 09:00-10:30 | ||
17.1: Replacement I Chairs: Mardas Daneshian, DE-Konstanz & Candida Nastrucci, IT-Rome |
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HALL 3 |
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09:00-09:20 |
Animals are not 'Materials and Methods': Why it is important to focus on Replacement Candida Nastrucci, IT-Rome |
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09:20-09:35 |
Examination of human bone tissue regeneration using the chorioallantoic membrane (CAM): an ex vivo replacement model for animal research Ines Moreno, UK-Southampton |
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09:35-09:55 |
Strategies for combining skin and vasculature in a Multi-Organ-Chip Platform Katharina Schimek, DE-Berlin |
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09:55-10:10 | Stem cell-derived human dorsal root ganglia-like cells to identify peripheral neurotoxicants Lisa Hoelting, DE-Konstanz |
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10:10-10:30 | Functional neurons from cancer cells: a novel in vitro model exhibits appropriate functional parameters Susanna Alloisio, IT-Genoa |
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10.1: Efficacy & Safety Testing I Chairs: Tuula Heinonen, FI-Tampere & Anett Ullrich, DE-Schwerin |
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HALL 2 |
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09:00-09:30 | A relevant in vitro model for safety testing of chemicals and efficacy testing of pharmaceuticals Tuula Heinonen, FI-Tampere |
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09:30-09:45 | Characterization of transporter activities in different cell types by using fluorescent substrates Anett Ullrich, DE-Schwerin |
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09:45-10:10 | Development, optimization and standardization of an in vitro skin irritation test for medical devices using the reconstructed human tissue model EpiDerm Helena Kandarova, SK-Bratislava |
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10:10-10:30 | HTS for screening of selective muscarinic cholinergic receptors antagonists Valerii Tonkopii, RU-St. Petersburg |
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15.2: Ethics & Legal Issues II Chairs: Roman Kolar, DE-Neubiberg & Stefanie Schindler, CH-Zurich |
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HALL 1 | ||
09:00-09:18 | Update on 3Rs activities at the EU institutional level and beyond the borders Francois Busquet, BE-Brussels |
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09:18-09:36 | 40 years of Animalfree Research. Results and lessons learned from a quality assessment Stefanie Schindler, CH-Zurich |
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09:36-09:54 | Non-animal Testing: It’s within REACH Julia Baines (replacing Gilly Stoddart), UK-Colchester |
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09:54-10:12 | REACH, the Cosmetics Regulation and upholding the animal testing ban Julia Baines, UK-Colchester |
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10:12-10:30 | Harm-benefit analysis of animal experimentation: a qualitative study of ethics committee practice in six European countries Anna Olsson, PT-Porto |
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10:30-11:00 | Coffee break and posters | |
Scientific sessions 11:00-12:30 | ||
7: Repeated Dose Toxicity & Other Toxicological Endpoints Chairs: Klaus-Rudolf Schröder, AT-Linz & Joachim Wiest, DE-Munich |
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HALL 1 | ||
11:00-11:25 | Towards the replacement of in vivo repeated dose systemic toxicity: Achievements of the SEURAT-1 research initiative Tilmann Gocht, DE-Tübingen |
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11:25-11:40 | Metabolomics in vitro: a new approach for systemic toxicity – first applications for mode of action identification and chemical grouping Tzutzuy Ramirez, DE-Ludwigshafen |
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11:40-11:55 | 28-day microphysiological monitoring of human hepatocellular cells Joachim Wiest, DE-Munich |
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11:55-12:05 | Generation of the molecular basis for studying thyroid hormone disruption in neural progenitor cells of humans and rats Susanne Giersiefer, DE-Düsseldorf |
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12:05-12:15 | Quantitative analysis of cell migration in the wound healing scratched assay by Using Active Contour Model and Speeded Up Robust Features Melika Farshad, IR-Shiraz |
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12:15-12:30 | Failure and Success: in vitro ocular irritation test methods for agrochemical formulations the Bovine Cornea Opacity and Permeability Test and the EpiOcular™ Eye Irritation Test Susanne Kolle, DE-Ludwigshafen |
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9.2: Skin Sensitization II Chairs: Helena Kandarova, SK-Bratislava & Gavin Maxwell, UK-Shambrook |
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HALL 3 |
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11:00-11:30 | Towards the assessment of skin sensitization potency: Quantitative estimations by the Direct Peptide Reactivity Assay Susanne Kolle, DE-Ludwigshafen |
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11:30-11:50 | From pathways to people: Applying the skin sensitisation AOP to risk assessment Gavin Maxwell, UK-Shambrook |
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11:50-12:10 | Functional characterization of reconstructed skin containing in vitro generated Langerhans cells Günther Weindl, DE-Berlin |
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12:10-12:30 | Evaluation of an in vitro human dermal sensitization test for use with medical device extracts Jamin A. Sr. Willoughby, US-Kalamazoo MI |
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16.2: Refinement II Chairs: Katy Taylor, UK-London & Christa Thöne-Reineke, DE-Berlin |
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HALL 2 |
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11:00-11:18 | Barriers to the implementation of refinements in animal laboratories Katy Taylor, UK-London |
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11:18-11:36 | Refinement strategies in experimental autoimmune encephalomyelitis (EAE) in mice Kristina Ullmann, DE-Berlin |
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11:36-11:54 | Community guidelines on animal studies - ALS research as a case-study Nuno Henrique Franco, PT-Porto |
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11:54-12:12 | The role of the animal welfare officer on the 3R´s principle in laboratory animal science in Germany Christa Thöne-Reineke, DE-Berlin |
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12:12-12:30 | Ethics review of animal experiments in Europe under Directive 2010/63/EU Anna Olsson, PT-Porto |
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12:30-13:30 | Business lunch (to be served at the congress venue) and posters |
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12:30-13:30 | ecopa General Assembly (members only) | |
Scientific sessions 13:30-15:00 | ||
3.2: 3D Models II Chairs: Christoph Giese, DE-Berlin & Jens Kelm, CH-Schlieren |
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HALL 1 | ||
13:30-13:48 | The HuALN model for testing immune reactivity in vitro Christoph Giese, DE-Berlin |
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13:48-14:06 | Optimization of an eye irritation assay for hazard identification and labelling of materials to address the EU Cosmetic Directive and REACH Legislation Yulia Kaluzhny, US-Ashland MA |
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14:06-14:24 | Versatile, polymer-based devices for multi-parameter in vitro toxicology Roisin Owens, FR-Gardanne |
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14:34-14:42 | A microfluidics integrated electronic monitoring system of a 3D in vitro model of the renal tubule Vincenzo Curto, FR-Gardanne |
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14:42-15:00 | Omnisphero: A novel computational approach for high content image analyses (HCA) of organoid neurosphere cultures in vitro Martin Roland Schmuck, DE-Düsseldorf |
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8: Inhalation Chairs: Rodger Curren, US-Gaithersburg MD & Samuel Constant, CH-Geneva |
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HALL 3 |
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13:30-13:50 | Cellular human based systems for investigating the toxicity effects of inhalable substances Samuel Constant, CH-Geneva |
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13:50-14:10 | Systems Toxicology-based assessment of aerosols using human organotypic tissue cultures of nasal and bronchial epithelium Julia Hoeng, CH-Lausanne |
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14:10-14:30 | Characterization of 3D reconstructed human airway models used for biomarker and inflammatory response studies Rodger Curren, US-Gaithersburg MD |
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14:30-14:45 | Preliminary validation studies of a 3D in vitro inhalation model, using cytokine and gene expression responses to metal-oxide particles Ingeborg Kooter, NL-Utrecht |
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14:45-15:00 | Building a framework of communication between industry and regulators to identify in vitro methods suitable for tobacco regulatory science Erin Hill, US-Gaithersburg MD |
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5.1: QSAR & Read Across I - Read Across Chairs: Matthias Herzler, DE-Berlin & Karel de Raat, FI-Helsinki |
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HALL 2 |
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13:30-14:00 | Preventing unnecessary testing by means of read-across: scope, justification and assessment Karel de Raat, FI-Helsinki |
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14:00-14:20 | New tools to assist in the application of the read-across approach Alessandra Roncaglioni, IT-Milano |
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14:20-14:35 | VPA Read across: Development of predictive biomarkers by using toxicity data of structurally similar compounds Regina Stöber, DE-Hannover |
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14:35-15:00 | Metabolomics as a read across tool Tzutzuy Ramirez, DE-Ludwigshafen |
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15:00-15:30 | Coffee break and posters | |
Scientific sessions 15:30-17:00 | ||
16.1: Refinement I and Culture of Care Chairs: Susanna Louhimies, BE-Brussels & Kirsty Reid, BE-Brussels |
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HALL 2 |
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15:30-15:50 | Working together to develop and implement a 'culture of care' Kirsty Reid, BE-Brussels |
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15:50-16:10 | Pain Management and post-operative monitoring and care of laboratory rodents in Germany – lessons learnt and recommendations to improve practice Kathrin Herrmann, DE-Berlin |
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16:10-16:30 | Ending severe suffering: the scientific animal welfare organization as a catalyst for change Elliot Lilley, UK-Horsham |
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16:30-16:50 | Refinement facilitated by the Culture of Care Susanna Louhimies, BE-Brussels |
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17.2: Replacement II Chairs: Thomas Hartung, US-Baltimore MD & Stefanie Schindler, CH-Zurich |
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HALL 3 |
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15:30-15:50 | 3D biocompatibility test systems mimicking the in vivo situation: evaluation of a hydroxyapatite-nanoparticular paste Veronika Hruschka, AT-Vienna |
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15:50-16:10 | A mismatch between micro-motives and macro-behaviour: The inefficiency of efforts toward replacement at the individual level Jan Lauwereyns, JP-Fukuoka |
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16:10-16:35 | New guidance on information requirements for skin corrosion/irritation and serious eye damage/eye irritation under REACH Bohumila Bichlmaier Suchanová, FI-Helsinki |
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16:35-17:00 | Replacement – coming closer to a dream Thomas Hartung, US-Baltimore MD |
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19.1: Young Scientists Short Lectures I Chairs: Helena Kandarova, SK-Bratislava & Manfred Liebsch, DE-Königs Wusterhausen |
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HALL 1 | ||
15:30-15:42 | A 3D in vitro iPSC derived mini-brain model to study Parkinson’s disease David Pamies, US-Baltimore MD |
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15:42-15:54 | Molecular modelling of osteoarthritis – evaluating pathways in vitro Annemarie Lang, DE-Berlin |
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15:54-16:06 | A novel human organotypic tumor invasion model of cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS) to reduce animal experiments in preclinical oncology Sebastian Konzok, DE-Hannover |
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16:06-16:18 | Impaired skin barrier function of cutaneous squamous cell carcinoma Christopher Wolff, DE-Berlin |
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16:18-16:30 | Generation of 3D neurospheres from human induced pluripotent stem cells as an alternative in vitro method to study neurodevelopmental defects of Cockayne Syndrome patient Maxi Hofrichter, DE-Düsseldorf |
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16:30-16:42 | Human lymphoblastoid cell lines as an in vitro tool in preclinical drug evaluation Tijana Markovic, SI-Ljubljana |
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16:42-16:54 | Systematic assessment of different computational approaches for prediction of toxic effects of new chemical structures Priyanka Banerjee, DE-Berlin |
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17:00-19:00 | Poster session II with coffee - authors present Survey of the posters with presence of the authors |
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19:30 | Departure to the Social Evening | |
20:00 | Social Evening | |
Wednesday, 23 September 2015 | ||
Scientific session 09:00-10:30 | ||
12.3: Disease Models III: Inflammation Chairs: Katherina Sewald, DE-Hannover & Manfred Liebsch, DE-Königs Wusterhausen |
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HALL 1 | ||
09:00-09:20 | Modular human biochip-based organoid models in sepsis research Alexander Mosig, DE-Jena |
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09:20-09:40 | Use of ex vivo organotypic lung tissue in translational research of respiratory injury and inflammation diseases Katherina Sewald, DE-Hannover |
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09:40-09:55 | Evaluation of selumetinib and trametinib MEK inhibitors antitumor efficacy in a preclinical in vitro human lung cancer model Samuel Constant, CH-Geneva |
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09:55-10:10 | Phenotypic responses of human asthmatic airway epithelial cultures to rhinovirus and poly(I:C) Patric Hayden, US-Ashland MA |
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10:10-10:30 | Small Airway-on-a-Chip: A novel human inflammatory disease model Kambez Benam, US-Boston MA |
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10:30-11:00 | Coffee break and posters | |
Scientific sessions 11:00-12:30 | ||
13: Biobarriers Chairs: Brunhilde Blömeke, DE-Trier & Maike Windbergs, DE-Saarbrücken |
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HALL 3 |
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11:00-11:15 | Biophysical and metabolic properties of striae distensae evaluated ex vivo compared to normal skin Youna Coquin, FR-Saint Gregoire |
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11:15-11:30 | Assess the bio-barrier function of the human respiratory system using an in vitro 3D model of airway epithelial model (MucilAir™) Samuel Constant, CH-Geneva |
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11:30-11:45 | Intelligent inserts as scaffolds for functional cell co-culture models on a biomimetic scale Silvia Angeloni, CH-Neuchâtel |
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11:45-12:00 | In vitro models of skin wounds – potential, limitations and perspectives Maike Windbergs, DE-Saarbrücken |
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12:00-12:15 | Epithelial-endothelal co-cultures to mimic the air-blood-barrier Brunhilde Blömeke, DE-Trier |
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12:15-12:30 | What happens when the particle has landed? – In vitro models for studying post-deposition events of aerosolized particles Marius Hittinger, DE-Saarbrücken |
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19.2: Young Scientists Short Lectures II Chairs: Helena Kandarova, SK-Bratislava & Lucia Lu Lee, DE-Berlin/CN-Hong Kong & Manfred Liebsch, DE-Königs Wusterhausen |
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HALL 1 | ||
11:00-11:12 | Chip-based co-culture of neurospheres and liver spheroids for long-term substance testing Anja Ramme, DE-Spreenhagen |
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11:12-11:24 | Human in vitro Blood-Brain Barrier model generated from stem cells: reducing attrition in the Central Nervous System area Aurore Drolez, FR-Lens |
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11:24-11:36 | A microfluidic four-organ-chip – a potential tool for ADME profiling Juliane Hübner, DE-Berlin |
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11:36-11:48 | In vitro investigation on uptake, cytotoxicity and genotoxicity of two similar sized titanium oxide nanoparticles on the human hepatic cells HepaRG Pegah Jalili, FR-Fougeres |
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11:48-12:00 | Optimization of a new in vitro method for inhalation toxicology and its application for the study of zinc oxide nanoparticle toxicity Emilie Da Silva, DK-København |
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12:00-12:12 | Assessment of sensitization and photosensitization of benzophenone-3 based on DPRA Carolina Benevenuto, BR-Brazil |
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12:24 | Closing Remarks and YSTA Lecture Award |
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13:30-17:45 | Day 1: EUSAAT 2015 Practical Training Course on Alternative Methods | |
13:30-18:00 | Part 1: SET Workshop "Translational Aspects of in vitro and in vivo Models for Inflammatory Diseases" (participation on invitation only) | |
Thursday, 24 September 2015 | ||
09:00-13:00 | Day 2: EUSAAT 2015 Practical Training Course on Alternative Methods | |
09:00-15:00 | Part 2: SET Workshop "Translational Aspects of in vitro and in vivo Models for Inflammatory Diseases" (participation on invitation only) |
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