Poster sessions

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Poster session I
Thursday, 25.08.2016
17:00-19:00

2. Global Cooperation on Implementing the 3Rs

1

International Trend of 3Rs: Asian Advancement

Tsutomu Kurosawa

2

Norecopa: providing global 3R-resources for animal research

Adrian Smith, Tim Allen, Karina Smith, Øyvind Wærenskjold, Bente Bergersen, Siri Knudsen, Anton Krag, Glenn Arve Sundnes

3. Ethical and Legal Issues

3

The US EPA’s methodology to inform TSCA premanufacturing notification decision-making: A critical analysis based on chemicals regulated by consent order

Robert Borotkanics, Paul Locke

4. Implementing EU Dir 63/2010

4

The Danish 3R-Center

Rasmus Normann Nielsen

5. Novel Approaches in Efficacy and Safety Testing

5

Predicting Adverse Immune Responses to Biologics

Ana Ribeiro, Shaheda Ahmed, Xiao Wang, Richard Stebbings, Anne Dickinson

6

Characterization of stably transfected HEK-293 cells expressing uptake transporters using fluorescent substances

Anett Ullrich, Jia Jia, Claudia Garve, Markus Keiser, Dieter Runge

7

Combining Human Cell-Based Assays to Identify Biocompatible Poly[acrylonitrile- co-(N-vinyl pyrrolidone)] Nanoparticles

Nan Zhang, André Said, Christian Wischke, Vivian Kral, Robert Brodwolf, Pierre Volz, Alexander Boreham, Christian Gerecke, Wenzhong Li, Axel Neffe, Burkhard Kleuser, Ulrike Alexiev, Andreas Lendlein, Monika Schaefer-Korting

8

Combination of Endpoints is Valuable Method for Estimating Hepatobiliary Toxicity in 3D Spheroid Cultures

Hiroko Hitotsumachi, Tomoaki Hitotsumachi, Hiroaki Oka, Fumio Morita, Kazuo Hakoi

9

The influence of in vitro complexity on detectable inflammatory responses induced by gold nanoparticles

Dania Movia, Roaa Alnemari, Yuri Volkov, Adriele Prina-Mello

10

In vitro demonstration of surfactant antagonism in the Open Source Reconstructed Epidermis (OS-REp) model

Roland Wedekind, Anja Fischer, Olaf Holtkötter, Karsten Rüdiger Mewes

11

3D vasculature-on-a-chip: development of a perfused human coronary artery endothelial microvessel model for vascular research and toxicological risk assessment in vitro

Carine Poussin, Vincent Van Duinen, Henriette Lanz, Marco Van der Toorn, Alexandra Laurent, Manuel C. Peitsch, Julia Hoeng, Jos Joore

12

Self-Assembled 3D Spheroids of MSC-Derived Hepatocyte-Like Cells for in vitro Toxicity Studies

Madalena Cipriano, Jorge M. Santos, Nuno G. Oliveira, Helder Cruz, Pedro E. Cruz, Matilde Castro, Joana Miranda

13

An Automated System for Monitoring Barrier Function in 3D Air-Liquid Interface Cultures

Frank Alexander, Joachim Wiest

14

Pre-Validation of human small intestinal tissue model system to screen drug induced gastrointestinal toxicity and wound healing

Seyoum Ayehunie, Zachary Stevens, Timothy Landry, Silvia Letasiova, Mitchell Klausner

15

Establishment and Characterization of a novel 3D Human in vitro Small Airway Model

Samuel Constant, Song Huang, Bernadett Boda, Jimmy Vernaz, Paul Alouani, Emilie Ferreira, Ludovic Wiszniewski

16

A microfluidic-based easy-to-use cardiac tissue model for drug screening applications

Michaela Purtscher, Ece Ergir, Dora Szwarc, Xavier Monforte Vila, Dominik Rünzler, Carina Huber-Gries

17

A microfluidic trapping device for electronic monitoring of 3D spheroids

Federica Mariani, Vincenzo Curto, Magali Ferro, Roisin Owens

18

3D networks of iPSC-derived neurons and glia for high-throughput neurotoxicity screening

Nienke Wevers, Karlijn Wilschut, Remko van Vught, Bas Trietsch, Henriëtte Lanz, Jos Joore, Paul Vulto

19

Skin penetration and tumor specific cellular uptake of tecto-dendrimer nanoparticles into a human cell-based model of non-melanoma skin cancer model

Priscila Schilrreff, Alexander Boreham, Christian Zoschke, Pierre Volz, Johannes Stellmacher, Robert Brodwolf, Christopher Wolff, Eder L. Romero, Monika Schaefer-Korting, Ulrike Alexiev

6. Stem Cells & Reproductive Toxicity (including mEST & hEST)

20

The effect of mesenchymal stem cells on breast cancer cell lines tested on the chick embryo chorioallantioc membrane: first results.

Christian Smolle, Frederike Reischies, Gebhard Schratter, Andreas Reicher, Verena Tiran, Nadia Dandachi, Daryousch Parvizi, Ruth Prassl, Lars-Peter Kamolz, Nassim Ghaffari-Tabrizi-Wizsy

21

DropTech® - An automated stem cell technology platform based on hanging drops for production and testing

Ina Meiser, Frank Stracke, Julia Neubauer, Luca Gentile, Erwin Gorjup, Eirini Koutsouraki, John Gardner, Paul de Sousa, Oliver Keminer, Carsten Claussen, Philip Gribbon, Ole Pless, Heiko Zimmermann

7. Refinement & Welfare

22

Clickertraining - a cognitive enrichment for laboratory mice?

Charlotte Sophie Leidinger, Christa Thöne-Reineke, Nadine Baumgart, Jan Baumgart

23

Stereotypic Mice: To use or not to use, that is the question.

Tina Nitezki, Fabian Schumacher, Julia Bornhorst, Burkhard Kleuser, Stephanie Krämer

24

AniMatch, an innovative web-based platform to share organs and tissues – Status update and challenges

Annemarie Lang, Benjamin Zimmer, Resa Ebadi, Jan Saam

25

PRIMTRAIN: A COST Action for training and animal behavioral management in non-human primates and other large laboratory animals

Valeska Marija Stephan, Björg Pauling, Robert Teepe, Stefan Treue

26

Mouse Dried Blood Spot (DBS) analysis to reduce animal testing

René Zahedi, Christoph Borchers

27

How to determine severity degrees for genetically altered rodents?

Anne Zintzsch, Claudia Gösele, Boris Jerchow, Stephanie Krämer, Reinhart Kluge, Hannah Nickles, Elena Noe, Astrid Puppe, Monika Reißmann, Kristina Ullmann

8. Replacement of Animals in Research & Use of Non-Animal Methods and Technologies

28

Isolation of astrocyte cell culture from human brain

Tomaz Velnar, Uros Maver, Lidija Gradisnik

29

Isolated human intervertebral disc cells as a useful platform for in vitro toxicology assessment

Lidija Gradisnik, Uros Maver, Tomaz Velnar

30

Stability of human skin explants: usability and effect of cultivation media

Jitka Vostálová, Eva Gabrielová, Adéla Galandáková, Bohumil Zálešák, Radka Lichnovská, Jitka Ulrichová, Alena Rajnochová Svobodová

31

Application of serum-free cultured human TK6 cells in the in vitro micronucleus test

Lisa Theis, Markus Schulz, Bennard van Ravenzwaay, Robert Landsiedel

32

Screening of endocrine disruptors and their impact on human health

Marketa Dvorakova, Kristina Kejlova, Marian Rucki, Hana Bendova, Pavel Kohout, Jitka Tomesova, Dagmar Jirova

33

Arxula Yeast Estrogen Screen (A-YES®) – a non-animal method to evaluate the estrogenic potential of chemical compounds

Mena Eidens, Martin Jähne, Corvin Eidens, Steffen Uhlig, Kirsten Simon

34

The human placenta ex vivo model: Analysis of ampicillin and cefotaxime transfer from the maternal to the fetal circulation.

Jana Pastuschek, Daniela Remane, Frank T. Peters, Udo R. Markert, Ekkehard Schleußner, Tanja Groten

35

Progress in preparation of electrically conductive biomimetic scaffolds for cell cultivation.

Petr Humpolíček, Věra Kašpárková, Marián Lehocký

36

Establishment of 2D and 3D cell culture assays using RT-gillW1 cells

Denise Mandt, Verena Pichler, Sophie Melchior, Dominik Rünzler

37

Development of a reconstructed human scalp with microfollicles using three-dimensional techniques.

Desirée Cigaran Schuck d'Avila, Bruna Sievers, Marcio Lorencini, Carla Abdo Brohem

38

The impact of ethanol in vitro and in vivo: a comparative study

Varvara Liousia, Elias Salzer, Denise Mandt, Dominik Rünzler

39

Morphological analysis of in vitro skin models generated by hair follicle-derived and skin-derived keratinocytes and fibroblasts

Anna Löwa, Maneenoch Khiao-In Khiao-In, Johanna Plendl, Sabine Käßmeyer, Sarah Hedtrich

9. Predictive Toxicology: QSAR & Read Across

40

Applicability of New Approach Methodologies to Support Read-Across – Conclusions from a Case Study Evaluated According to the ECHA Read-Across Assessment Framework

Andrea-Nicole Richarz, Elisabet Berggren, Andrew Worth

41

Use of alternative methods for the prediction of combined effects from chemical mixtures

Stephanie Bopp, Aude Kienzler, Sander Van der Linden, Andrew Worth

42

Reducing uncertainty in read-across-based chemical safety assessments

Monica Autiero, Sangamitra Mishra, Magali Balteau, Francesca Tencalla, Thomas Petry

43

Mechanism-based modeling for non-animal prediction of skin sensitization potency

David Roberts

Poster session II
Friday, 26.08.2016
17:30-19:00

10. Toxicology I - Systemic Toxicity, Environmental Toxicity, Inhalation Toxicity

44

PBTK modeling of potential endocrine modulators: In vitro-in vivo extrapolation (IVIVE) and in silico-in vitro based risk assessments:

Eric Fabian, Christian Haase, Tzutzuy Ramirez, Bennard van Ravenzwaay, Robert Landsiedel

45

Uncertainties and complexities of the 2 years rodent cancer bioassay – hitchhiking OECD work on systematic description of in vitro testing strategies to explain limitations of in vivo reference data

Martin Paparella, Annamaria Colacci, Miriam N. Jacobs

46

Enhancing effect of 100 kHz alternating electric field on the ChIFN – γ – like molecule inducing capacity of LCL (Lens culinaris lectine) and 10% PBS washout of holocene minerals

Bratko Filipič, Lidija Gradišnik, Miroslav Petrovec, Adriana Pereyra, Klemen Rihar, Almin Puzić, Hrvoje Mazija, Časlav Daničič

47

Preliminary data on the successful micronucleus testing with the EPISKIN® reconstructed epidermis model

Eric Andres, Nicolas Orsini, Rola Barcham, Mouctar Barry, Christophe Dini, Anne-Pascale Luzy

48

Live or dead is not enough: A large-scale mobility assay with Daphnia magna

Elias Salzer, Dominik Rünzler

49

Testing as a Service – flexibility through seamless integration for cell based assays

Lena Schober, Moriz Walter, Andrea Traube

50

LUCS (Light-Up Cell System), a novel live cell assay for acute and other regulatory toxicity applications

Sylvain Derick, Camille Gironde, Pierre Pério, Karine Reybier, Françoise Nepveu, Cecile Dufour, Christophe Furger

51

Perspectives to use the fish embryo tests for the prediction of acute fish toxicity

Stefan Scholz, Ralph Kühne, David Leuthold, Nils Klüver

11. Toxicology II - Skin Senzitization, Phototoxicity, Bio-Barriers, Novel testing Concepts

Is Balb/c 3T3 cell line suitable model for phototoxicity testing?

Alena Rajnochová Svobodová, Jitka Ulrichová, Jitka Vostálová

53

Non-Animal Testing for Skin Sensitization: Replacement or mere Supplement?

Daniel Urbisch, Naveed Honarvar, Susanne N Kolle, Annette Mehling, Wera Teubner, Robert Landsiedel

54

skin sensitization

Françoise Bree

55

Assessment of the phototoxicity of three different TiO2 nano-forms using reconstructed human tissue model EpiDerm

Alzbeta Liskova, Helena Kandarova, Tatiana Milasova, Vlasta Brezova, Sona Jantova

56

CON4EI: Short Time Exposure (STE) Model

Jamin Willoughby

57

CON4EI: EpiOcular Eye Irritation Test (EIT)

Helena Kandarova, An Van Rompay, Els Adriaens, Nathalie Alepee, Agnieszka Drzewiecka, Przemyslaw Fochtman, Katarzyna Gruszka, Robert Guest, Gareth Maglennon, Jane Schofield, Jamin Willoughby, Sandra Verstraelen

58

Implementation of the RHE / IL-18 sensitization assay on the Skinethic™ RHE test system – Prediction model optimization

Eric Andres, Rola Barcham, Mouctar Barry, Erwin L Roggen, Christophe Dini, Pierre-Jacques Ferret

59

Successful evaluation of sensitization by DPRA assay coupled with Mass Spectrometry detection

Eric Andres, Rola Barcham, Antoine Obry, Alexander Hundt, Christophe Dini

60

Use of ECVAM validated EpiDerm Skin Corrosion Test (EpiDerm SCT) for sub-categorization according to the UN GHS

Silvia Letasiova, Helena Kandarova, Patrick Hayden, Mitchell Klausner

61

Determination of contact sensitization potential of chemicals using in vitro reconstructed normal human epidermal model EpiDerm: impact of the modality of application

Silvia Letasiova, Emanuela Corsini, Valentina Galbiati, Helena Kandarova, Dagmar Lehmeier, Helge Gehrke

62

A proteomics approach reveals characteristic changes in THP-1 cells after treatment with contact sensitizers

Tessa Höper, Franz Mussotter, Andrea Haase, Andreas Luch

63

An In Vitro Reconstructed Normal Human Corneal Tissue Model: Applications to Dry Eye, Wound Healing, and Ophthalmic Drug Delivery

Yulia Kaluzhny, Miriam Kinuthia, AM Gremilogianni, M Megkoulas, Alena Plotkin, Anna Maione, Patrick Hayden, Helena Kandarova, Mitchell Klausner

64

Potency ranking of skin sensitizers using the Reconstituted human Epidermis (RhE) IL-18 test and the Genomic Allergen Rapid Detection (GARD) test.

Erwin L Roggen, Els Adriaens, Eric Andres, Daniel Bouchard, Sun-A Cho, Emanuela Corsini, George DeGeorge, Horst Fuchs, Pierre-Jacques Ferret, Sue Gibbs, Patrick Hayden, Olivia Larne, Hanna Hofman Huether, Silvia Letasiova, Malin Lindsted, Jean-Philippe Therrien

13. Disease Models in vitro versus in vivo

65

Identification of pro-fibrotic biomarkers in precision-cut lung slices (PCLS)

Christina Hesse, Samuel Mang, Monika Niehof, Heinz-Gerd Hoymann, Peter Braubach, Danny Jonigk, Gregor Warnecke, Olaf Pfennig, Hans-Gerd Fieguth, Armin Braun, Katherina Sewald

66

Ex vivo infection with rhinovirus in mouse precision-cut lung slices

Olga Danov, Annika Volkwein, Lisa Laßwitz, Susanne Romberg, Helena Obernolte, Armin Braun, Sabine Wronski, Katherina Sewald

67

Development and standardization of a predictive and bio-relevant wound healing assay for preclinical development

Viktoria Planz, Jing Wang, Maike Windbergs

68

Pro-Test Deutschland, a Voice for Science

Renee Hartig

69

Effects of association of lipoperoxide nanoemulsion and cisplatinum for a cancer targeted therapy in DLD-1 human colon adenocarcinoma cells

Stefania Vernazza, Chiara Scanarotti, Sara Tirendi, Laura Pastorino, Elena Dellacasa, Carmelina Ruggiero, Anna Maria Bassi

70

Defining the optimal animal model for translational research using gene set enrichment analysis

Christopher Weidner, Matthias Steinfath, Elisa Opitz, Michael Oelgeschläger, Gilbert Schönfelder

14. 3Rs in Education and Academia

71

3Rs in surgical skill trainings

Györgyi Szabó, Domokos Csukás, Andrea Ferencz, Gamal Eldin Mohamed, József Sándor, Daniella Fehér, Krisztina Juhos, György Wéber

72

Emedia skills lab for Laboratory Animal Science – Alternatives to Animal Experiments in Teaching and Learning

Teresa Federsel, Martin Lemos, Christian Bleilevens, Julia Steitz, Ulla Ohnesorge-Radtke, Rene Tolba

73

Effects of implementation of EU Directive 63/2010 on education at University of Debrecen

Ádám Deák, Norbert Németh, Irén Mikó, István Furka

74

Commitment of Italian Academic LARF-DIMES for Teaching and Training in Alternative Approach to Animal Testing.

Anna Maria Bassi, Chiara Scanarotti, Stefania Vernazza, Susanna Penco, Susanna Alloisio

75

3Rs Education in Veterinary Science: a course on in vitro toxicology

Francesca Caloni

15. 'Young Scientists' session - Free communications

76

Anticancer effects of co-administration of Daunorubicin and Resveratrol in MOLT-4, U266 B1 and Raji cell lines

Ramin Rezaee

77

Hepatocyte-like cells derived from human adipose stem cells: a new model for genotoxicity testing

Jana Tomc, Katja Kološa, Bojana Žegura, Metka Filipič

78

An improved aerosol deposition device to assess safety and efficacy of dry powder formulations at the air/liquid interface

Marius Hittinger, Sarah Barthold, Alexander Gress, Birgit Wiegand, Lorenz Siebenbürger, Carsten Börger, Markus Berger, Tobias Krebs, Claus-Michael Lehr, Henrik Groß

79

A novel method to predict fatty liver drugs using metabolic network based target identification.

Priyanka Banerjee, Robert Preissner, Herrmann-Georg Holzhütter

80

Infection of epithelial cells and fresh human lung tissue with persistent Pseudomonas aeruginosa

Laura Boge, Meike Müller, Peter Braubach, Danny Jonigk, Hans-Gerd Fieguth, Gregor Warnecke, Marcus Krüger, Jan Knebel, Armin Braun, Katherina Sewald, Sabine Wronski

81

Human placental explants as an alternative for animal testing

Karolin Fröhlich, Andre Schmidt, Julia Heger, Amelie Lupp, Gitta Turowski, Udo Markert

82

Rupintrivir reduces rhinovirus infection in human Precision-Cut Lung Slices

Helena Obernolte, Peter Braubach, Danny Jonigk, Marcus Krüger, Gregor Warnecke, Olaf Pfennig, Hans-Gerd Fieguth, Armin Braun, Katherina Sewald, Sabine Wronski

83

Placental models to analyze the effects of chemotherapeutics on trophoblastic cells during pregnancy

Julia Heger, Karolin Fröhlich, Lisa Uhl, Ralf Mrowka, Andre Schmidt, Udo R. Markert

84

Improving cell culture experiments by replacing fetal calf serum with human serum

Julia Heger, Jana Pastuschek, Lisa-Marie Görke, Karolin Fröhlich, Andre Schmidt, Udo R. Markert